One-step adhesive bonding system (GC Ortho Connect) vs Conventional multi-step adhesive systems (three-step Transbond XT; self-etch primer Transbond Plus): White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions)
- Population
- Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
- Intervention
- One-step adhesive bonding system (GC Ortho Connect)
- Comparison
- Conventional multi-step adhesive systems (three-step Transbond XT; self-etch primer Transbond Plus)
- Outcome
- White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions)
A single RCT found the one-step adhesive without a primer (GC Ortho Connect) produced more and more severe white spot lesions than conventional multi-step systems (ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
One-step self-adhesive resin without a separate primer (GC Ortho Connect) vs Conventional multi-step adhesive systems (three-step Transbond XT; self-etch primer Transbond Plus) White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 2 and 4 months, Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults A single RCT found the one-step adhesive without a primer (GC Ortho Connect) produced more and more severe white spot lesions than conventional multi-step systems (ungraded). Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024) All outcomes | Horan 2023 (1 three-arm RCT, 75 patients): the one-step adhesive without primer (GC Ortho Connect) had a significantly higher WSL incidence and larger, deeper lesions than both the three-step and self-etch systems… | 1 study · 75 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic Treatment? A… 2024 All outcomes | October 2023 | 12 | High / Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Comparison of three orthodontic bonding systems in white spot lesion development: a randomized clinical trial. · 2023 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.