Question · asked by 1 review
Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone: Locoregional control
- Population
- People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
- Intervention
- Concomitant (concurrent) chemoradiotherapy
- Comparison
- Radiotherapy alone
- Outcome
- Locoregional control
Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone (non-resectable tumours) Locoregional control, concurrent chemoradiotherapy (platinum + 5-fluorouracil) vs radiotherapy alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2021) · Cochrane All outcomes | RR 0.75 [0.61, 0.93] | 3 studies | GRADE not reported |
Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone (non-resectable tumours) Locoregional control, concomitant chemoradiotherapy vs radiotherapy alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concomitant chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2011) · Cochrane All outcomesearlier version CD006386.PUB3, superseded | HR 0.73 [0.64, 0.82] | 7 studies | GRADE not reported |
Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone (non-resectable tumours) Locoregional control, concomitant chemoradiotherapy vs radiotherapy alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concomitant chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2010) · Cochrane All outcomesearlier version CD006386.PUB2, superseded | HR 0.73 [0.64, 0.82] | 7 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes | 2021-09 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.