Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls): Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss)
- Population
- Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
- Intervention
- Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping)
- Comparison
- Children and adolescents aged 0-18 years without CLP (controls)
- Outcome
- Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss)
Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls) Periodontal/gingival clinical status (gingival index, biofilm index, probing depth, bleeding on probing, attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP) · Multiple countries; pediatric cleft/craniofacial care; saliva, dental plaque, subgingival plaque and nasal/oropharyngeal samples Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded. Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and… (2024) All outcomes | Six studies (Ahluwalia, Rawashdeh, Funahashi, Perdikogianni, Quirynen, Costa) reported that patients with CLP had higher gingival index and biofilm/plaque index, deeper probing depth, more bleeding on probing and… | 6 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and… 2024 All outcomes | Publications from 1 January 1985 to 30 June 2020 (search date not separately reported) | 24 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.