Question · asked by 1 review
Renin inhibitors vs ACE inhibitor: Fatal or non‐fatal serious adverse events
- Population
- people with primary hypertension
- Intervention
- Renin inhibitors
- Comparison
- ACE inhibitor
- Outcome
- Fatal or non‐fatal serious adverse events
Renin inhibitors showed no clear difference in fatal or non‐fatal serious adverse events compared with ACE inhibitors (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Renin inhibitors vs ACE inhibitors Fatal or non‐fatal serious adverse events · people with primary hypertension Renin inhibitors showed no clear difference in fatal or non‐fatal serious adverse events compared with ACE inhibitors (low certainty). Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension (2020) · Cochrane Headline outcomes only | RR 1.21 [0.89, 1.64] | 10 studies · 6007 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.