Methotrexate vs placebo: Participants able to reduce corticosteroid or IVIg dose by more than 20%
Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methotrexate vs placebo Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty). Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic… (2017) · Cochrane Headline outcomes only | RR 1.21 [0.4, 3.7] | 1 study · 59 participants | Moderate |
Methotrexate vs placebo Participants able to reduce corticosteroid or IVIg dose by more than 20% · patients with CIDP Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty). Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic… (2013) · Cochrane Headline outcomes onlyearlier version CD003280.PUB4, superseded | RR 1.21 [0.4, 3.7] | 1 study · 59 participants | Moderate |
Methotrexate vs placebo Participants able to reduce corticosteroid or IVIg dose by more than 20% · patients with CIDP Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty). Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic… (2010) · Cochrane Headline outcomes onlyearlier version CD003280.PUB3, superseded | RR 1.21 [0.4, 3.7] | 1 study · 59 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating… 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.