Older adults with anticholinergic burden vs older adults with no anticholinergic burden: Cognitive decline or dementia
Older adults with anticholinergic burden may leads to higher cognitive decline or dementia compared with older adults with no anticholinergic burden (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Older adults with anticholinergic burden vs older adults with no anticholinergic burden Cognitive decline or dementia · older adults without cognitive impairment at baseline Older adults with anticholinergic burden may leads to higher cognitive decline or dementia compared with older adults with no anticholinergic burden (low certainty). Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults… (2021) · Cochrane Headline outcomes only | OR 2.63 [1.09, 6.29] | 4 studies · 125359 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.