Low molecular weight heparin vs vitamin K antagonist (VKA): Minor bleeding
- Population
- Patients with cancer requiring long‐term anticoagulation for VTE
- Intervention
- Low molecular weight heparin
- Comparison
- vitamin K antagonist (VKA)
- Outcome
- Minor bleeding
Low molecular weight heparin showed no clear difference in minor bleeding compared with vitamin K antagonist (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Low molecular weight heparin vs vitamin K antagonist Minor bleeding · patients with cancer requiring long‐term anticoagulation for VTE Low molecular weight heparin showed no clear difference in minor bleeding compared with vitamin K antagonist (low certainty). Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer (2014) · Cochrane Headline outcomes onlyearlier version CD006650.PUB4, superseded | RR 0.89 [0.51, 1.55] | 4 studies · 1091 participants | Low |
LMWH vs VKA Minor bleeding · Patients with cancer requiring long‐term anticoagulation for VTE LMWH showed no clear difference in minor bleeding compared with VKA (low certainty). Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer (2011) · Cochrane Headline outcomes onlyearlier version CD006650.PUB3, superseded | RR 0.85 [0.53, 1.35] | 4 studies · 1120 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Low molecular weight heparin vs no LMWH · people with cancer with thrombosis prophylaxis and central venous catheters · 1 review
- Low molecular weight heparin vs vitamin K antagonist (VKA) · people with cancer with thrombosis prophylaxis and central venous catheters · 1 review
- Low molecular weight heparin vs no prophylaxis · adults undergoing KA · 1 review
- Low molecular weight heparin vs unfractionated heparin · adults with kidney failure treated with long‐term HD · 1 review
- Low molecular weight heparin vs control · children with a CVC · 1 review
- Low molecular weight heparin vs No active treatment (control) · preventing VTE in adults undergoing KA · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.