Question · asked by 1 review
Summary of findings ‐ initiation of penicillin prophylaxis vs placebo: Adverse effects
- Population
- children with SCD
- Intervention
- Summary of findings ‐ initiation of penicillin prophylaxis
- Comparison
- placebo
- Outcome
- Adverse effects
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings ‐ initiation of penicillin prophylaxis vs placebo Adverse effects · children with SCD Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease (2021) · Cochrane Headline outcomes only | no estimate extracted | 2 studies · 457 participants | Low |
Summary of findings ‐ initiation of penicillin prophylaxis vs placebo Adverse effects · children with SCD Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease (2017) · Cochrane Headline outcomes onlyearlier version CD003427.PUB4, superseded | no estimate extracted | 2 studies · 457 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.