Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy: Oral candidiasis prevalence
- Population
- Children and adolescents (<18 years) living with HIV (CLWH)
- Intervention
- Combined antiretroviral therapy (cART)
- Comparison
- Monotherapy or dual antiretroviral therapy
- Outcome
- Oral candidiasis prevalence
cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty). Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) All outcomes | OR 0.22 [0.16, 0.29] | 4 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis. 2022 All outcomes | 2022-08-03 (inception to 3 August 2022) | 14 | Critically Low / Low |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Combined antiretroviral therapy (cART) vs No antiretroviral medication (treatment-naive) · Children and adolescents (<18 years) living with HIV (CLWH) · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.