Question · asked by 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment: Adverse events as N of participants with at least one adverse event objective

Population
patients with the treatment of cocaine dependence
Intervention
Summary of findings table – disulfiram
Comparison
placebo or no pharmacological treatment
Outcome
Adverse events as N of participants with at least one adverse event objective

It is very uncertain whether summary of findings table – disulfiram changes any adverse events (number of participants who experienced at least… compared with placebo or no pharmacological treatment (very low certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Summary of findings table – disulfiram vs placebo or no pharmacological treatment
Any adverse events (number of participants who experienced at least one adverse event) · people with cocaine dependence
It is very uncertain whether summary of findings table – disulfiram changes any adverse events (number of participants who experienced at least… compared with placebo or no pharmacological treatment (very low certainty).
Disulfiram for the treatment of cocaine dependence (2024) · Cochrane Headline outcomes only
RR 3 [0.35, 25.68]1 study · 30 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Disulfiram for the treatment of cocaine dependence
2024 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed

The same intervention and outcome, asked in another population or against another comparator.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.