Question · asked by 1 review
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L): Dental caries
- Population
- Children (<19 years)
- Intervention
- Vitamin D deficiency (serum 25(OH)D < 50 nmol/L)
- Comparison
- Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L)
- Outcome
- Dental caries
Children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels (unadjusted RR 1.22; ungraded).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) Dental caries · Children (<19 years) Children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels (unadjusted RR 1.22; ungraded). Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review… (2023) All outcomes | RR 1.22 [1.18, 1.25] | 13 studies · 19205 participants | GRADE not reported |
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) Dental caries · Children (<19 years) · Cross-sectional studies Among cross-sectional studies, vitamin D deficiency was associated with a 19% higher risk of dental caries (RR 1.19; ungraded). Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review… (2023) All outcomes | RR 1.19 [1.14, 1.24] | 5 studies | GRADE not reported |
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) Dental caries · Children (<19 years) · Cohort studies Among cohort studies, vitamin D deficiency was associated with a 62% higher risk of dental caries (RR 1.62; ungraded). Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review… (2023) All outcomes | RR 1.62 [1.51, 1.74] | 5 studies | GRADE not reported |
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) Dental caries · Children (<19 years) · Adjusted for confounders After adjustment for confounders, vitamin D deficiency remained associated with a higher risk of dental caries (adjusted RR 1.16; ungraded). Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review… (2023) All outcomes | RR 1.16 [1.10, 1.22] | Not reported | GRADE not reported |
Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) Dental caries · Children (<19 years) · Case-control studies Among case-control studies, the association was weak and borderline (RR 1.05, 95% CI 1.00 to 1.09; ungraded). Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review… (2023) All outcomes | RR 1.05 [1.00, 1.09] | 3 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis. 2023 All outcomes | 6 January 2023 (no time restrictions) | 13 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) · Children (mixed dentition; baseline about 8 years) · 1 review
- Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) · Children with permanent dentition (>12 years) · 1 review
- Vitamin D deficiency (serum 25(OH)D < 50 nmol/L) vs Normal vitamin D level (serum 25(OH)D ≥ 50 nmol/L) · Children with deciduous dentition (<6 years) · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area. · 2021 · included by 1 of these review
- Associations Between Prenatal, Perinatal, and Early Childhood Vitamin D Status and Risk of Dental Caries at 6 Years. · 2021 · included by 1 of these review
- Serum cotinine, vitamin D exposure levels and dental caries experience in U.S. adolescents. · 2019 · included by 1 of these review
- Vitamin D status and dental caries in healthy Swedish children. · 2018 · included by 1 of these review
- A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children. · 2018 · included by 1 of these review
- Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: A case-control study. · 2018 · included by 1 of these review
- Suboptimal Serum Vitamin D Associated with Early Childhood Caries in Special Health Care Needs Children. · 2018 · included by 1 of these review
- Vitamin D and Dental Caries in Children. · 2016 · included by 1 of these review
- Evaluation of an interdisciplinary preventive programme for early childhood caries: findings of a regional German birth cohort study. · 2016 · included by 1 of these review
- Association of vitamin D and dental caries in children: Findings from the National Health and Nutrition Examination Survey, 2005-2006. · 2016 · included by 1 of these review
- Re-Examining the Association between Vitamin D and Childhood Caries. · 2015 · included by 1 of these review
- Vitamin D status of children with severe early childhood caries: a case-control study. · 2013 · included by 1 of these review
- The relationship between vitamin D and severe early childhood caries: a pilot study. · 2012 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.