Question · asked by 1 review
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model): Dental caries susceptibility
- Population
- Children and adults (no age limit) assessed for dental caries susceptibility
- Intervention
- TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype)
- Comparison
- CT genotype vs TT genotype (heterozygous model)
- Outcome
- Dental caries susceptibility
No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the heterozygous (CT vs TT) model (OR 0.93, 95% CI 0.56 to 1.56); ungraded.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the heterozygous (CT vs TT) model (OR 0.93, 95% CI 0.56 to 1.56); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 0.93 [0.56, 1.56] | 2 studies · 538 participants | GRADE not reported |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the heterozygous (CT vs TT) model (OR 1.40, 95% CI 0.91 to 2.15); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 1.40 [0.91, 2.15] | 2 studies · 929 participants | GRADE not reported |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Permanent tooth caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for permanent tooth caries under the heterozygous (CT vs TT) model (OR 1.65, 95% CI 0.33 to 8.35); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 1.65 [0.33, 8.35] | 3 studies · 1271 participants | GRADE not reported |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Ethnicity: Asian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the heterozygous (CT vs TT) model (OR 1.67, 95% CI 0.96 to 2.90); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 1.67 [0.96, 2.90] | 5 studies · 1932 participants | GRADE not reported |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Overall No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries overall under the heterozygous (CT vs TT) model (OR 1.41, 95% CI 0.89 to 2.22); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 1.41 [0.89, 2.22] | 7 studies · 2470 participants | GRADE not reported |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model) Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the heterozygous (CT vs TT) model (OR 1.34, 95% CI 0.75 to 2.40); ungraded. Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. (2021) All outcomes | OR 1.34 [0.75, 2.40] | 2 studies · 270 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis. 2021 All outcomes | Updated 31 August 2020 | 11 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT/CC genotype vs TT genotype (dominant model) · Children and adults (no age limit) assessed for dental caries susceptibility · 1 review
- TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs CT/TT genotype (recessive model) · Children and adults (no age limit) assessed for dental caries susceptibility · 1 review
- TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs C allele vs T allele (allele contrast model) · Children and adults (no age limit) assessed for dental caries susceptibility · 1 review
- TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs TT genotype (homozygous model) · Children and adults (no age limit) assessed for dental caries susceptibility · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.