Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome: Alpha diversity (Shannon)
In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples · Oral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies, Children In children, caries-vs-health Shannon alpha diversity differed significantly (ungraded). Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) All outcomes | In children, the Shannon alpha-diversity index differed significantly between caries and health (p < 0.001). | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomes | Not specified (studies published from 2012 onward included; no explicit search date reported) | 16 | Not applicable |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.