Same question across reviews · CL0020
aetiology :: Exposure: microbial -> Other outcome
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
3
Questions
5
current versions
GRADE rated
0
Review overlap (CCA)
0.000
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
High salivary S. mutans level vs Lower salivary S. mutans level Sites with attachment loss greater than 3 mm · Humans with salivary S. mutans measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 0.74 [0.35, 1.60] | 1 study | Ungraded |
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries) Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) | Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18… | 2 studies · 25 participants | Ungraded |
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries) Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) | Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)… | 2 studies · 9 participants | Ungraded |
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples · Adults Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) | In adults, there was no significant caries-vs-health difference in Chao1 or Observed diversity, whereas the Shannon index differed significantly (p < 0.001). | NR | Ungraded |
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples · Children Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) | In children, the Shannon alpha-diversity index differed significantly between caries and health (p < 0.001). | NR | Ungraded |