Genetically predicted periodontitis vs Without periodontitis (lower genetic liability): Lacunar stroke
- Population
- European-ancestry adults
- Intervention
- Genetically predicted periodontitis
- Comparison
- Without periodontitis (lower genetic liability)
- Outcome
- Lacunar stroke
Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Genetically predicted periodontitis vs Without periodontitis (lower genetic liability) Lacunar stroke · European-ancestry adults (GWAS) · Genetic epidemiology (European-ancestry GWAS summary data) Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037). The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) All outcomes | OR 1.24 [1.03, 1.49] | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study. 2025 All outcomes | August 2024 | 10 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.