Intravenous diclofenac vs placebo: At least 50% reduction in pain
- Population
- Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or orthopedic surgeries
- Intervention
- Intravenous diclofenac
- Comparison
- placebo
- Outcome
- At least 50% reduction in pain
Intravenous diclofenac may leads to higher number of participants with at least 50% pain relief at 4 hours compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Intravenous diclofenac vs placebo Number of participants with at least 50% pain relief at 4 hours · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or… Intravenous diclofenac may leads to higher number of participants with at least 50% pain relief at 4 hours compared with placebo (low certainty). Single‐dose intravenous diclofenac for acute postoperative pain in adults (2018) · Cochrane Headline outcomes only | RR 2.8 [2, 4] | 3 studies · 277 participants | Low |
Intravenous diclofenac vs placebo Number of participants with at least 50% pain relief at 6 hours · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental, mixed minor, abdominal, or… Intravenous diclofenac may leads to higher number of participants with at least 50% pain relief at 6 hours compared with placebo (low certainty). Single‐dose intravenous diclofenac for acute postoperative pain in adults (2018) · Cochrane Headline outcomes only | RR 1.8 [1.4, 2.2] | 4 studies · 436 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Single‐dose intravenous diclofenac for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Intravenous diclofenac vs NSAIDs · Adults (mean study ages 25 to 55 years) with acute postoperative pain after dental,… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.