Amantadine vs placebo: Abstinence
Amantadine showed no clear difference in abstinence (objective) N of subjects abstinent at the end of the study compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amantadine vs placebo Abstinence (objective) N of subjects abstinent at the end of the study · patients with the treatment of cocaine dependence Amantadine showed no clear difference in abstinence (objective) N of subjects abstinent at the end of the study compared with placebo (low certainty). Dopamine agonists for the treatment of cocaine dependence (2015) · Cochrane Headline outcomes only | RR 1.13 [0.59, 2.13] | 5 studies · 275 participants | Low |
Amantadine vs placebo Abstinence at · patients with the treatment of cocaine dependence Amantadine probably leads to higher abstinence at compared with placebo (moderate certainty). Dopamine agonists for the treatment of cocaine dependence (2015) · Cochrane Headline outcomes only | RR 1.49 [1.03, 2.15] | 3 studies · 76 participants | Moderate |
Amantadine vs placebo Abstinence at · patients with the treatment of cocaine dependence Amantadine showed no clear difference in abstinence at compared with placebo (moderate certainty). Dopamine agonists for the treatment of cocaine dependence (2011) · Cochrane Headline outcomes onlyearlier version CD003352.PUB3, superseded | RR 1.43 [0.99, 2.08] | 3 studies · 76 participants | Moderate |
Amantadine vs placebo Abstinence (objective) objective · patients with the treatment of cocaine dependence Amantadine showed no clear difference in abstinence (objective) objective compared with placebo (moderate certainty). Dopamine agonists for the treatment of cocaine dependence (2011) · Cochrane Headline outcomes onlyearlier version CD003352.PUB3, superseded | RR 1.08 [0.77, 1.51] | 5 studies · 275 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.