Antihistamines vs placebo: Adverse effects: 1. Sedation
- Population
- patients with motion sickness
- Intervention
- Antihistamines
- Comparison
- placebo
- Outcome
- Adverse effects: 1. Sedation
Antihistamines may leads to higher adverse effects: sedation Assessed by: adverse effect questionnaire… compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antihistamines vs placebo Adverse effects: sedation Assessed by: adverse effect questionnaire (presence or absence given numerical values) · patients with motion sickness Antihistamines may leads to higher adverse effects: sedation Assessed by: adverse effect questionnaire… compared with placebo (low certainty). Antihistamines for motion sickness (2022) · Cochrane Headline outcomes only | RR 1.51 [1.12, 2.02] | 2 studies · 190 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antihistamines for motion sickness 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Antihistamines vs scopolamine · patients with motion sickness · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.