Question · asked by 1 review
Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only): Disease-free survival
- Population
- People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
- Intervention
- Surgery +/- radiotherapy + (adjuvant) chemotherapy
- Comparison
- Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)
- Outcome
- Disease-free survival
Surgery +/- radiotherapy + (adjuvant) chemotherapy led to lower disease-free survival, adjuvant concurrent chemoradiation vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only) Disease-free survival, adjuvant concurrent chemoradiation vs adjuvant radiotherapy (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Surgery +/- radiotherapy + (adjuvant) chemotherapy led to lower disease-free survival, adjuvant concurrent chemoradiation vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2021) · Cochrane All outcomes | HR 0.84 [0.72, 0.97] | 4 studies | GRADE not reported |
Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only) Disease-free survival, surgery +/- RT + adjuvant chemotherapy vs surgery +/- RT alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in disease-free survival, surgery +/- RT + adjuvant chemotherapy vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2011) · Cochrane All outcomesearlier version CD006386.PUB3, superseded | HR 0.89 [0.78, 1.01] | 8 studies | GRADE not reported |
Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only) Disease-free survival, surgery +/- RT + adjuvant chemotherapy vs surgery +/- RT alone (pooled) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in disease-free survival, surgery +/- RT + adjuvant chemotherapy vs… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy…; GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy (2010) · Cochrane All outcomesearlier version CD006386.PUB2, superseded | HR 0.87 [0.73, 1.04] | 3 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes | 2021-09 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.