Question · asked by 1 review
Bisphosphonates vs placebo or no treatment: Adverse effects of treatment
- Population
- adults with β‐thalassaemia and osteoporosis
- Intervention
- Bisphosphonates
- Comparison
- placebo or no treatment
- Outcome
- Adverse effects of treatment
It is very uncertain whether summary of findings – bisphosphonates changes adverse effects of treatment compared with placebo or no treatment (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings – bisphosphonates vs placebo or no treatment Adverse effects of treatment · adults with β‐thalassaemia and osteoporosis It is very uncertain whether summary of findings – bisphosphonates changes adverse effects of treatment compared with placebo or no treatment (very low certainty). Treatment for osteoporosis in people with beta‐thalassaemia (2023) · Cochrane Headline outcomes only | OR 15 | 2 studies · 143 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.