Question · asked by 1 review
Vitamin D vs placebo: Adverse events
- Population
- people with sickle cell disease
- Intervention
- Vitamin D
- Comparison
- placebo
- Outcome
- Adverse events
Vitamin D showed no clear difference in adverse events compared with placebo (low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin D vs placebo Adverse events · people with sickle cell disease Vitamin D showed no clear difference in adverse events compared with placebo (low certainty). Vitamin D supplementation for sickle cell disease (2020) · Cochrane Headline outcomes only | RR 3.16 [0.14, 72.84] | 1 study · 37 participants | Low |
Vitamin D vs placebo Adverse events · people with sickle cell disease Vitamin D showed no clear difference in adverse events compared with placebo (low certainty). Vitamin D supplementation for sickle cell disease (2017) · Cochrane Headline outcomes onlyearlier version CD010858.PUB2, superseded | RR 3.16 [0.14, 72.84] | 1 study · 37 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.