Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection: Disease-free survival
- Population
- Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
- Intervention
- Elective neck dissection (at time of primary tumour resection)
- Comparison
- Therapeutic (delayed) neck dissection
- Outcome
- Disease-free survival
Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection Disease-free survival (new disease, progression, and mortality) · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes · 3 years Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty). Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane All outcomes | HR 0.56 [0.45, 0.70] | 5 studies · 954 participants | Moderate |
Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2011) · Cochrane All outcomesearlier version CD006205.PUB3, superseded | Two trials found no difference (Fakih 1989; Vandenbrouck 1980); Kligerman 1994 found benefit for elective supraomohyoid ND. Not pooled. | 3 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes | 2022-02 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.