Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo: Progression to Alzheimer's disease Number of people progressing to AD
Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in progression to Alzheimer's disease Number of people progressing to AD compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo Progression to Alzheimer's disease Number of people progressing to AD · people with mild cognitive impairment Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in progression to Alzheimer's disease Number of people progressing to AD compared with placebo (moderate certainty). Vitamin E for Alzheimer's dementia and mild cognitive impairment (2017) · Cochrane Headline outcomes onlyearlier version CD002854.PUB4, superseded | RR 1.03 [0.79, 1.35] | 1 study · 516 participants | Moderate |
Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo Progression to Alzheimer's disease Number of people progressing to AD · people with mild cognitive impairment Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in progression to Alzheimer's disease Number of people progressing to AD compared with placebo (moderate certainty). Vitamin E for Alzheimer's dementia and mild cognitive impairment (2017) · Cochrane Headline outcomes only | RR 1.03 [0.79, 1.35] | 1 study · 516 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vitamin E for Alzheimer's dementia and mild cognitive impairment 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.