Cochrane · systematic review · CD002854
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Farina, N, Llewellyn, D, Isaac, MGEKN, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
6
No studies
2
Included studies
NR
No studies 2 · 22.2%Ungraded 1 · 11.1%Very low 0 · 0%Low 0 · 0%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVitamin E (capsules 2000 IU/day in two divided doses) compared to placebo for people with Alzheimer's disease
Population: people with Alzheimer's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive function LS mean change from baseline using the ADAS‐Cog Scale from: 0 to 70 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 272 participants | Moderate Downgraded: imprecision |
Adverse events Number of participants reporting ≥ 1 serious adverse event Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 0.86 [0.71, 1.05] | 1 study · 304 participants | Moderate Downgraded: imprecision |
Deaths Number of deaths Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 0.84 [0.52, 1.34] | 1 study · 304 participants | Moderate Downgraded: imprecision |
Activities of daily living LS mean change from baseline using the ADCS‐ADL Scale from: 0 to 78 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 280 participants | Moderate Downgraded: imprecision |
Vitamin E (capsules 2000 IU/day in two divided doses) compared to placebo for people with mild cognitive impairment
Population: people with mild cognitive impairment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Progression to Alzheimer's disease Number of people progressing to AD Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 1.03 [0.79, 1.35] | 1 study · 516 participants | Moderate Downgraded: imprecision |
Cognitive function Mean change from baseline of ADAS‐Cog Scale from: 0 to 70 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | NR | No studies |
Adverse events Number of participants reporting ≥ 1 serious adverse event. Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 516 participants | Ungraded |
Death Number of deaths over 36 months Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 1.01 [0.3, 3.44] | 1 study · 516 participants | Moderate Downgraded: imprecision |
Activities of daily living Mean change from baseline using the ADCS Mild Cognitive Impairment Activities of Daily Living Scale from: 0 to 53 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | NR | No studies |
Vitamin E (capsules 2000 IU/day in two divided doses) compared to placebo for people with Alzheimer's disease
Population: people with Alzheimer's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive function LS mean change from baseline using the ADAS‐Cog Scale from: 0 to 70 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 272 participants | Moderate Downgraded: imprecision |
Adverse events Number of participants reporting ≥ 1 serious adverse event Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 0.86 [0.71, 1.05] | 1 study · 304 participants | Moderate Downgraded: imprecision |
Deaths Number of deaths Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 0.84 [0.52, 1.34] | 1 study · 304 participants | Moderate Downgraded: imprecision |
Activities of daily living LS mean change from baseline using the ADCS‐ADL Scale from: 0 to 78 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 280 participants | Moderate Downgraded: imprecision |
Vitamin E (capsules 2000 IU/day in two divided doses) compared to placebo for people with mild cognitive impairment
Population: people with mild cognitive impairment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Progression to Alzheimer's disease Number of people progressing to AD Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 1.03 [0.79, 1.35] | 1 study · 516 participants | Moderate Downgraded: imprecision |
Cognitive function Mean change from baseline of ADAS‐Cog Scale from: 0 to 70 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | NR | No studies |
Adverse events Number of participants reporting ≥ 1 serious adverse event. Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | 1 study · 516 participants | Ungraded |
Death Number of deaths over 36 months Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | RR 1.01 [0.3, 3.44] | 1 study · 516 participants | Moderate Downgraded: imprecision |
Activities of daily living Mean change from baseline using the ADCS Mild Cognitive Impairment Activities of Daily Living Scale from: 0 to 53 Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo | no estimate extracted | NR | No studies |