Question · asked by 1 review
Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D): Dental caries in children
- Population
- Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
- Intervention
- Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy)
- Comparison
- Adequate prenatal vitamin D (sufficient maternal 25(OH)D)
- Outcome
- Dental caries in children
For prenatal vitamin D measured across gestational weeks 6-38, the OR of dental caries was 1.32 (no CI reported); ungraded.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Prenatal vitamin D deficiency (maternal 25(OH)D measured at gestational weeks 6 to 38) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D) Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Maternal 25(OH)D measured at gestational weeks 6 to 38, Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey), Gestational-age subgroup: weeks 6 to 38 For prenatal vitamin D measured across gestational weeks 6-38, the OR of dental caries was 1.32 (no CI reported); ungraded. Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024) All outcomes | OR 1.32 [1.04, 1.59] | 4 studies | GRADE not reported |
Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D) Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Prenatal exposure; dental caries assessed in children aged 2 to 8 years, Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey), Overall (all studies pooled) Prenatal vitamin D deficiency is associated with significantly higher odds of dental caries in children (pooled OR 1.35, 95% CI 1.22-1.47), but heterogeneity is high (I2=86.6%) and publication bias is present; the observational evidence is ungraded. Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024) All outcomes | OR 1.35 [1.22, 1.47] | 12 studies · 11021 participants | GRADE not reported |
Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D) Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Prenatal exposure; dental caries in children aged 2 to 8 years, Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey), Publication-bias adjustment: Trim & Fill corrected pooled estimate After Trim & Fill correction for publication bias, the association persisted (OR 1.28, 95% CI 1.14-1.48); ungraded. Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic… (2024) All outcomes | OR 1.28 [1.14, 1.48] | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis. 2024 All outcomes | 5 October 2023 (search range 2000 to October 2023) | 16 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D) · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed · 1 review
- Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D) · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native… · 2022 · included by 1 of these review
- Associations Between Prenatal, Perinatal, and Early Childhood Vitamin D Status and Risk of Dental Caries at 6 Years. · 2021 · included by 1 of these review
- Vitamin D, pregnancy and caries in children in the INMA-Asturias birth cohort. · 2021 · included by 1 of these review
- Association of Maternal Vitamin D Deficiency with Early Childhood Caries. · 2019 · included by 1 of these review
- Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children · 2015 · included by 1 of these review
- Prenatal Vitamin D and Dental Caries in Infants · 2014 · included by 1 of these review
- Interobserver agreement of the TASC II classification for supra- and infrainguinal lesions. · 2010 · included by 1 of these review
- Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection. · 2010 · included by 1 of these review
- Direct measurement of the accuracy of CO(2)laser alignment on target. · 1978 · included by 1 of these review
- Beckett 2022 · included by 1 of these review
- Christensen 2016 · included by 1 of these review
- Olczak-Kowalczyk 2021 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.