Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes): Miscarriage
Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Supplementation with folate vs no intervention, placebo or other micronutrients without folate (maternal outcomes) Miscarriage (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty). Effects and safety of periconceptional oral folate supplementation for preventing birth defects (2015) · Cochrane Headline outcomes only | RR 1.1 [0.94, 1.28] | 5 studies · 7391 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Effects and safety of periconceptional oral folate supplementation for preventing birth defects 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.