Lamotrigine vs phenobarbital: 50% or greater reduction in seizure frequency
- Population
- patients with AD and epileptic seizures
- Intervention
- Lamotrigine
- Comparison
- phenobarbital
- Outcome
- 50% or greater reduction in seizure frequency
It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Lamotrigine vs phenobarbital Reduction in seizure frequency of 50% or more · patients with AD and epileptic seizures It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty). Treatment of epilepsy for people with Alzheimer's disease (2021) · Cochrane Headline outcomes only | RR 0.91 [0.6, 1.38] | 1 study · 57 participants | Very low |
Lamotrigine vs phenobarbital Reduction in seizure frequency of 50% or more · patients with AD and epileptic seizures It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty). Treatment of epilepsy for people with Alzheimer's disease (2018) · Cochrane Headline outcomes onlyearlier version CD011922.PUB3, superseded | RR 0.91 [0.6, 1.38] | 1 study · 57 participants | Very low |
Lamotrigine vs phenobarbital Reduction in seizure frequency of 50% or more · patients with AD and epileptic seizures It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty). Treatment of epilepsy for people with Alzheimer's disease (2016) · Cochrane Headline outcomes onlyearlier version CD011922.PUB2, superseded | RR 0.91 [0.6, 1.38] | 1 study · 57 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Lamotrigine vs valproate · absence seizures in children and adolescents · 1 review
- Lamotrigine vs placebo · people with drug‐resistant focal epilepsy · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.