Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Chemoprophylaxis effect of EGCG on various digestive system diseases: a systematic review and meta-analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Zhang et al. 2023 matched by author and year (probable) | NR | 6 | none stated | not extracted yet |
| Chen 2015 matched by author and year (probable) | NR | 3 | none stated | not extracted yet |
| Zhao 2010 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Zhou 2013 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism. Chen 2025 · Chen Junzhou, Yin Conghui, et al. · Nutrients PMID:39940407 | 2025 | 1 | none stated | not extracted yet |
| Immunoregulatory Effect and Mechanism of Epigallocatechin-3-Gallate in A Mouse Oral Cancer Model Li 2024 · Li Yizhen, Huang Siyi, et al. · Proceedings of Anticancer Research DOI:10.26689/par.v8i5.8323 | 2024 | 1 | none stated | not extracted yet |
| Green Tea Catechin EGCG Ameliorates Thioacetamide‐Induced Hepatic Encephalopathy in Rats via Modulation of the Microbiota‐Gut‐Liver Axis Zhou 2023 · Zhou Zhengming, Li Ke, et al. · Molecular Nutrition & Food Research DOI:10.1002/mnfr.202200821 | 2023 | 1 | none stated | not extracted yet |
| Green Tea Catechin EGCG Ameliorates Thioacetamide-Induced Hepatic Encephalopathy in Rats via Modulation of the Microbiota-Gut-Liver Axis. Zhou 2023 · Zhou Zhengming, Li Ke, et al. · Molecular nutrition & food research PMID:36573265 | 2023 | 1 | none stated | not extracted yet |
| Inhibition of macrophages inflammasome activation via autophagic degradation of HMGB1 by EGCG ameliorates HBV-induced liver injury and fibrosis. He 2023 · He Minjing, Chu Tianhao, et al. · Frontiers in immunology PMID:37122751 | 2023 | 1 | none stated | not extracted yet |
| Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and… Diwan 2022 · Diwan Bhawna, Sharma Rohit · Biogerontology DOI:10.1007/s10522-022-09976-9 | 2022 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis George 2022 · George Joseph, Tsuchishima Mutsumi, et al. · Biomedicine & Pharmacotherapy DOI:10.1016/j.biopha.2022.113111 | 2022 | 1 | none stated | not extracted yet |
| EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway Wei 2022 · Wei Hua, Ge Qi, et al. · The Journal of Nutritional Biochemistry DOI:10.1016/j.jnutbio.2021.108843 | 2022 | 1 | none stated | not extracted yet |
| Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGFβ / p-ERK/p-Smad1/2 signaling,… Mostafa-Hedeab 2022 · Mostafa-Hedeab Gomaa, Ewaiss Hassan Manal, et al. · Saudi Pharmaceutical Journal DOI:10.1016/j.jsps.2022.06.021 | 2022 | 1 | none stated | not extracted yet |
| EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway. Wei 2022 · Wei Hua, Ge Qi, et al. · The Journal of nutritional biochemistry PMID:34407449 | 2022 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis. George 2022 · George Joseph, Tsuchishima Mutsumi, et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie PMID:35594711 | 2022 | 1 | none stated | not extracted yet |
| Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and… Diwan 2022 · Diwan Bhawna, Sharma Rohit · Biogerontology PMID:35779147 | 2022 | 1 | none stated | not extracted yet |
| Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGFβ / p-ERK/p-Smad1/2 signaling,… Mostafa-Hedeab 2022 · Mostafa-Hedeab Gomaa, Ewaiss Hassan Manal, et al. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society PMID:36249942 | 2022 | 1 | none stated | not extracted yet |
| Probing the chemoprevention potential of the antidepressant fluoxetine combined with epigallocatechin gallate or kaempferol in rats with induced… Hassan 2021 · Hassan Eman S.G., Hassanein Nahed M., et al. · Journal of Pharmacological Sciences DOI:10.1016/j.jphs.2020.10.005 | 2021 | 1 | none stated | not extracted yet |
| Epigallocatechin‐3‐Gallate Alleviates High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy… Wu 2021 · Wu Dongdong, Liu Zhengguo, et al. · Oxidative Medicine and Cellular Longevity DOI:10.1155/2021/5599997 | 2021 | 1 | none stated | not extracted yet |
| Probing the chemoprevention potential of the antidepressant fluoxetine combined with epigallocatechin gallate or kaempferol in rats with induced… Hassan 2021 · Hassan Eman S G, Hassanein Nahed M, et al. · Journal of pharmacological sciences PMID:33357777 | 2021 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile and Macrophage Polarization. Du 2021 · Du Yong, Paglicawan Laura, et al. · Nutrients PMID:33670347 | 2021 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy… Wu 2021 · Wu Dongdong, Liu Zhengguo, et al. · Oxidative medicine and cellular longevity PMID:33953830 | 2021 | 1 | none stated | not extracted yet |
| Green tea polyphenol epigallocatechin-3-gallate alleviates nonalcoholic fatty liver disease and ameliorates intestinal immunity in mice fed a… Huang 2020 · Huang Jinbao, Li Wenjiao, et al. · Food & Function DOI:10.1039/d0fo02152k | 2020 | 1 | none stated | not extracted yet |
| Green tea polyphenol epigallocatechin-3-gallate alleviates nonalcoholic fatty liver disease and ameliorates intestinal immunity in mice fed a… Huang 2020 · Huang Jinbao, Li Wenjiao, et al. · Food & function PMID:33095225 | 2020 | 1 | none stated | not extracted yet |
| A mouse model of subacute liver failure with ascites induced by step-wise increased doses of (-)-epigallocatechin-3-gallate Wang 2019 · Wang Xiaoxiao, Yang Lumin, et al. · Scientific Reports DOI:10.1038/s41598-019-54691-0 | 2019 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-Gallate (EGCG), An Active Constituent of Green Tea: Implications in the Prevention of Liver Injury Induced by Diethylnitrosamine… Almatroodi 2019 · A. Almatroodi Saleh, A. Alsahli Mohammed, et al. · Applied Sciences DOI:10.3390/app9224821 | 2019 | 1 | none stated | not extracted yet |
| Low dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability. Du 2019 · Du Yong, Ding Huihua, et al. · Nutrients PMID:31362373 | 2019 | 1 | none stated | not extracted yet |
| A mouse model of subacute liver failure with ascites induced by step-wise increased doses of (-)-epigallocatechin-3-gallate. Wang 2019 · Wang Xiaoxiao, Yang Lumin, et al. · Scientific reports PMID:31792332 | 2019 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-Gallate Toxicity in Children: A Potential and Current Toxicological Event in the Differential Diagnosis With Virus-Triggered… Sergi 2019 · Sergi Consolato M · Frontiers in pharmacology PMID:32063842 | 2019 | 1 | none stated | not extracted yet |
| Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice Rasheed 2018 · Rasheed Nora O. Abdel, Ahmed Lamiaa A., et al. · Scientific Reports DOI:10.1038/s41598-018-25901-y | 2018 | 1 | none stated | not extracted yet |
| Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice. Rasheed 2018 · Rasheed Nora O Abdel, Ahmed Lamiaa A, et al. · Scientific reports PMID:29777127 | 2018 | 1 | none stated | not extracted yet |
| EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF- <i>κ</i> B Signaling… Bing 2017 · Bing Xue, Xuelei Liu, et al. · Canadian Journal of Gastroenterology and Hepatology DOI:10.1155/2017/3057268 | 2017 | 1 | none stated | not extracted yet |
| Dietary Copper Reduces the Hepatotoxicity of (-)-Epigallocatechin-3-Gallate in Mice. Kaleri 2017 · Kaleri Najeeb Ahmed, Sun Kang, et al. · Molecules (Basel, Switzerland) PMID:29295524 | 2017 | 1 | none stated | not extracted yet |
| EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats. Bing 2017 · Bing Xue, Xuelei Liu, et al. · Canadian journal of gastroenterology & hepatology PMID:29404307 | 2017 | 1 | none stated | not extracted yet |
| Repeated dose studies with pure Epigallocatechin-3-gallate demonstrated dose and route dependant hepatotoxicity with associated dyslipidemia Ramachandran 2016 · Ramachandran Balaji, Jayavelu Subramani, et al. · Toxicology Reports DOI:10.1016/j.toxrep.2016.03.001 | 2016 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-gallate attenuates apoptosis&nbsp;and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3 Li 2016 · Li Sainan, Xia Yujing, et al. · Drug Design, Development and Therapy DOI:10.2147/dddt.s99420 | 2016 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. Li 2016 · Li Sainan, Xia Yujing, et al. · Drug design, development and therapy PMID:26929598 | 2016 | 1 | none stated | not extracted yet |
| Repeated dose studies with pure Epigallocatechin-3-gallate demonstrated dose and route dependant hepatotoxicity with associated dyslipidemia. Ramachandran 2016 · Ramachandran Balaji, Jayavelu Subramani, et al. · Toxicology reports PMID:28959554 | 2016 | 1 | none stated | not extracted yet |
| Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet Ding 2015 · Ding Yi, Sun Xin, et al. · European Journal of Pharmacology DOI:10.1016/j.ejphar.2015.05.005 | 2015 | 1 | none stated | not extracted yet |
| Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice Church 2015 · Church Rachel J., Gatti Daniel M., et al. · Food and Chemical Toxicology DOI:10.1016/j.fct.2014.11.008 | 2015 | 1 | none stated | not extracted yet |
| Green tea polyphenol (−)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue… Wang 2015 · Wang Dongxu, Wang Yijun, et al. · Toxicology and Applied Pharmacology DOI:10.1016/j.taap.2014.12.018 | 2015 | 1 | none stated | not extracted yet |
| Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Church 2015 · Church Rachel J, Gatti Daniel M, et al. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association PMID:25446466 | 2015 | 1 | none stated | not extracted yet |
| Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: responses of major antioxidant enzymes and the Nrf2 rescue… Wang 2015 · Wang Dongxu, Wang Yijun, et al. · Toxicology and applied pharmacology PMID:25585349 | 2015 | 1 | none stated | not extracted yet |
| Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. Ding 2015 · Ding Yi, Sun Xin, et al. · European journal of pharmacology PMID:25967348 | 2015 | 1 | none stated | not extracted yet |
| Protective effects of (-)-epigallocatechin-3-gallate against acetaminophen-induced liver injury in rats). Yao 2015 · Yao Hsien-Tsung, Yang Yu-Chi, et al. · BioMedicine PMID:26264479 | 2015 | 1 | none stated | not extracted yet |
| Epigallocatechin-3-gallate-induced inhibition of interleukin-6 release and adjustment of the regulatory T/T helper 17 cell balance in the treatment… Xu 2015 · Xu Zhenglei, Wei Cheng, et al. · Experimental and therapeutic medicine PMID:26668622 | 2015 | 1 | none stated | not extracted yet |
| Possible hepatocellular toxicity of EGCG under the influence of an inflammagen Saleh 2014 · Saleh Ibrahim G., Ali Zulfiqar, et al. · Journal of Applied Biomedicine DOI:10.1016/j.jab.2014.03.001 | 2014 | 1 | none stated | not extracted yet |
| (—)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis Sumi 2013 · Sumi Takafumi, Shirakami Yohei, et al. · SpringerPlus DOI:10.1186/2193-1801-2-690 | 2013 | 1 | none stated | not extracted yet |
| (-)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis. Sumi 2013 · Sumi Takafumi, Shirakami Yohei, et al. · SpringerPlus PMID:25674420 | 2013 | 1 | none stated | not extracted yet |
| Capecitabine combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts. Wu 2012 · Wu Hongju, Xin Yan, et al. · Experimental and therapeutic medicine PMID:22969946 | 2012 | 1 | none stated | not extracted yet |