Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Effects of Nutritional Supplements Alone or as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial. Stańdo et al. 2020 · Stańdo Mirella, Piatek Paweł, et al. · Nutrients PMID:32867199 | 2020 | 4 | none stated | not extracted yet |
| Efficacy of Cucurmin and Aloevera Extracts Gel as Local Drugs Delivery Agents. Borgohain 2023 · Borgohain Raktapratim, Fatima Nikhat, et al. · Journal of pharmacy & bioallied sciences PMID:37693983 | 2023 | 3 | 1 | not extracted yet |
| Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: A clinical and microbiological study. Rahalkar 2021 · Rahalkar Apurva, Kumathalli Kanteshwari, et al. · Journal of Indian Society of Periodontology PMID:34158685 | 2021 | 3 | 1 | not extracted yet |
| Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β… Umrania et al. 2017 · Umrania Vanali Vinodbhai, Rao Deepika Pawar Chandrashekara, et al. · Journal of Indian Society of Periodontology PMID:29491585 | 2017 | 3 | none stated | not extracted yet |
| Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in… Elavarasu 2016 · Elavarasu Sugumari, Suthanthiran Thangakumaran, et al. · Journal of pharmacy & bioallied sciences PMID:27829747 | 2016 | 3 | 1 | not extracted yet |
| Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: A… Prasanth 2024 · Prasanth T., Singh H., et al. · Medical Journal Armed Forces India DOI:10.1016/j.mjafi.2024.04.013 | 2024 | 2 | none stated | not extracted yet |
| Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial Eldessouky 2024 · Eldessouky Hadir F., Marie Magda · BioMed Research International DOI:10.1155/2024/6997142 | 2024 | 2 | none stated | not extracted yet |
| Clinical and microbiological outcomes of subgingival instrumentation supplemented with high-dose omega-3 polyunsaturated fatty acids in periodontal… Stando-Retecka 2023 · Stańdo-Retecka Mirella, Piatek Paweł, et al. · BMC Oral Health DOI:10.1186/s12903-023-03018-7 | 2023 | 2 | none stated | not extracted yet |
| Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial Gonde 2022 · Gonde Noopur P., Rathod Surekha R., et al. · Journal of Periodontology DOI:10.1002/jper.21-0515 | 2022 | 2 | none stated | not extracted yet |
| A clinical and microbiological study to assess the efficacy of Acmella oleracea and Acacia catechu herbs as local drug delivery in treatment of… Verma 2022 · Verma Kanika, Dhruvakumar Deepa, et al. · Journal of Indian Society of Periodontology PMID:35602538 | 2022 | 2 | none stated | not extracted yet |
| Evaluation of Grape Seed Formulation as an Adjunct to Scaling and Root Planing on Oxidative Stress, Inflammatory Status and Glycaemic Control in… Acharya 2021 · Acharya Sameekshya, Gujjari Sheela Kumar, et al. · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH DOI:10.7860/jcdr/2021/45235.14792 | 2021 | 2 | none stated | not extracted yet |
| Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease. Anton 2021 · Anton Diana-Maria, Martu Maria-Alexandra, et al. · Medicina (Kaunas, Lithuania) PMID:33562452 | 2021 | 2 | none stated | not extracted yet |
| A comparison of the efficacy of scaling and root planning with application of pomegranate chip, pomegranate gel, and scaling and root planing in… Tyagi 2021 · Tyagi Prashant, Dodwad Vidya, et al. · Journal of Indian Society of Periodontology PMID:33642740 | 2021 | 2 | none stated | not extracted yet |
| Using ginger supplement in adjunct with non-surgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2… Gholinezhad 2020 · Gholinezhad Hasan, Bazyar Hadi, et al. · Journal of Herbal Medicine DOI:10.1016/j.hermed.2019.100315 | 2020 | 2 | none stated | not extracted yet |
| Efficacy of an herbal antioxidant as an adjunct to nonsurgical periodontal therapy on procalcitonin levels in smokers with chronic periodontitis. Sravya 2019 · Sravya M V N, Koduganti Rekha Rani, et al. · Journal of Indian Society of Periodontology PMID:31543616 | 2019 | 2 | none stated | not extracted yet |
| Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth… Singh 2018 · Singh Abhilasha, Sridhar Raja, et al. · The Journal of Alternative and Complementary Medicine DOI:10.1089/acm.2017.0059 | 2018 | 2 | 1 | not extracted yet |
| Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled,… Deore 2014 · Deore Girish D, Gurav Abhijit N, et al. · Journal of periodontal & implant science PMID:24778901 | 2014 | 2 | none stated | not extracted yet |
| Efficacy of a local-drug delivery gel containing extracts of Quercus brantii and Coriandrum sativum as an adjunct to scaling and root planing in… Yaghini 2014 · Yaghini Jaber, Shahabooei Mohammad, et al. · Journal of research in pharmacy practice PMID:25114940 | 2014 | 2 | none stated | not extracted yet |
| Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: a placebo controlled clinical trial. Mahendra 2013 · Mahendra Jaideep, Mahendra Little, et al. · Journal of clinical and diagnostic research : JCDR PMID:24298522 | 2013 | 2 | none stated | not extracted yet |
| Abdallah 2024 DOI:10.3290/j.cjdr.b5459607 | NR | 2 | 1 | not extracted yet |
| Elgendy 2018 DOI:10.3290/j.ohpd.a40957 | NR | 2 | none stated | not extracted yet |
| Comparison of the effectiveness of <i>Morus alba</i> and chlorhexidine gels as an adjunct to scaling and root planing on stage <scp>II</scp>… Gunjal 2024 · Gunjal Shilpa, Hampiholi Vinuta, et al. · International Journal of Dental Hygiene DOI:10.1111/idh.12781 | 2024 | 1 | none stated | not extracted yet |
| Efficacy and Viability of Subgingival Application of Probiotics as an Adjunct to Scaling and Root Planing in Periodontitis Poulose 2024 · Poulose Mariam, Gujar Dnyaneshwari, et al. · Indian Journal of Dental Research DOI:10.4103/ijdr.ijdr_533_23 | 2024 | 1 | none stated | not extracted yet |
| To Evaluate the Effect of Vitamin B Complex on Wound Healing - A Clinical and Microbiological Study. Kalsi 2024 · Kalsi Rupali, Bhushan Kala S, et al. · Journal of pharmacy & bioallied sciences PMID:38595592 | 2024 | 1 | none stated | not extracted yet |
| Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial Laky 2024 · Laky Brenda, Bruckmann Corinna, et al. · Journal of Periodontology DOI:10.1002/jper.23-0115 | 2023 | 1 | none stated | not extracted yet |
| Effect of oral gargle containing Lespedeza cuneata extract on periodontal health improvement and disease prevention: a randomized, controlled… Kim 2023 · Kim Yu-Rin, Nam Seoul-Hee · BMC Oral Health DOI:10.1186/s12903-023-02816-3 | 2023 | 1 | none stated | not extracted yet |
| Assessment of Outcome of Oral Supplementation of Vitamin D3 as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Type II… Ramaprabha 2023 · Ramaprabha G, Khan Nubesh S, et al. · Journal of pharmacy & bioallied sciences PMID:37654407 | 2023 | 1 | none stated | not extracted yet |
| Antioxidant effect of spirulina in chronic periodontitis Kaipa 2022 · Kaipa Vinay Rama Krishna, Asif Shaik Mohammed, et al. · Medicine DOI:10.1097/md.0000000000031521 | 2022 | 1 | none stated | not extracted yet |
| Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized… Ramos 2022 · Ramos Tatiane Caroline de Souza, Boas Mariéllen Longo Vilas, et al. · Journal of Applied Oral Science DOI:10.1590/1678-7757-2021-0583 | 2022 | 1 | none stated | not extracted yet |
| Domiciliary Management of Periodontal Indexes and Glycosylated Hemoglobin (HbA1c) in Type 1 Diabetic Patients with Paraprobiotic-Based Toothpaste… Butera 2022 · Butera Andrea, Pascadopoli Maurizio, et al. · Applied Sciences DOI:10.3390/app12178610 | 2022 | 1 | none stated | not extracted yet |
| Impact of a Specific Collagen Peptide Food Supplement on Periodontal Inflammation in Aftercare Patients-A Randomised Controlled Trial. Jockel-Schneider 2022 · Jockel-Schneider Yvonne, Stoelzel Peggy, et al. · Nutrients PMID:36364735 | 2022 | 1 | none stated | not extracted yet |
| Effects of natural herb-containing dental toothpaste on periodontal pathogenic bacteria and clinical parameters: A randomized clinical trial Shirakawa 2021 · Shirakawa Satoshi, Matsushima Yuji, et al. · Journal of Herbal Medicine DOI:10.1016/j.hermed.2021.100517 | 2021 | 1 | none stated | not extracted yet |
| Evaluation of the efficacy of lycopene gel compared with minocycline hydrochloride microspheres as an adjunct to nonsurgical periodontal treatment:… Ali 2021 · Ali Aya, Saliem Saif, et al. · Journal of Dental Sciences DOI:10.1016/j.jds.2020.09.009 | 2021 | 1 | none stated | not extracted yet |
| Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: a pilot… Morales 2021 · Morales Alicia, Contador Rafael, et al. · BMC Oral Health DOI:10.1186/s12903-020-01276-3 | 2021 | 1 | none stated | not extracted yet |
| Intrapocket application of tea tree oil gel in the treatment of stage 2 periodontitis Taalab 2021 · Taalab Maha R., Mahmoud Sabah Abdelhady, et al. · BMC Oral Health DOI:10.1186/s12903-021-01588-y | 2021 | 1 | none stated | not extracted yet |
| Anti-inflammatory potential of an essential oil-containing mouthwash in elderly subjects enrolled in supportive periodontal therapy: a 6-week… Jünger 2020 · Jünger Hendrik, Jaun-Ventrice Anna, et al. · Clinical Oral Investigations DOI:10.1007/s00784-019-03194-3 | 2020 | 1 | none stated | not extracted yet |
| Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial Isola 2021 · Isola Gaetano, Polizzi Alessandro, et al. · Clinical Oral Investigations DOI:10.1007/s00784-020-03397-z | 2020 | 1 | none stated | not extracted yet |
| Effect of short‐term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double‐masked, placebo‐controlled clinical trial Gao 2020 · Gao Weimin, Tang Huilin, et al. · Journal of Periodontal Research DOI:10.1111/jre.12719 | 2020 | 1 | none stated | not extracted yet |
| Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL‐1<i>β</i>, and TNF‐<i>α</i> in Chronic Periodontitis Patients Mohammad 2020 · Mohammad Chenar Anwar · BioMed Research International DOI:10.1155/2020/8850926 | 2020 | 1 | none stated | not extracted yet |
| <p>The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients… Bazyar 2020 · Bazyar Hadi, Maghsoumi-Norouzabad Leila, et al. · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy DOI:10.2147/dmso.s230060 | 2020 | 1 | none stated | not extracted yet |
| Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis – A clinical study Nagate 2020 · Nagate Raghavendra Reddy, Yuvaraja M, et al. · Tropical Journal of Pharmaceutical Research DOI:10.4314/tjpr.v19i2.27 | 2020 | 1 | none stated | not extracted yet |
| Clinical and microbiological effects of 1% Matricaria chamomilla mouth rinse on chronic periodontitis: A double-blind randomized placebo controlled… Agarwal 2020 · Agarwal Ashish, Chaudhary Bharti · Journal of Indian Society of Periodontology PMID:32831509 | 2020 | 1 | none stated | not extracted yet |
| Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C:… Grusovin 2020 · Grusovin Maria Gabriella, Bossini Simone, et al. · Clinical Oral Investigations DOI:10.1007/s00784-019-03065-x | 2019 | 1 | none stated | not extracted yet |
| Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis Javid 2019 · Javid Ahmad Zare, Hormoznejad Razie, et al. · Diabetes & Metabolic Syndrome: Clinical Research & Reviews DOI:10.1016/j.dsx.2019.07.042 | 2019 | 1 | none stated | not extracted yet |
| Evaluation of biodegradable gel containing flax seed extract (Linum usitatissimum) as a targeted drug delivery for management of chronic periodontitis Pappu 2019 · Pappu R, Varghese J, et al. · Journal of Herbal Medicine DOI:10.1016/j.hermed.2018.100254 | 2019 | 1 | none stated | not extracted yet |
| Lycopene solid lipid microparticles with enhanced effect on gingival crevicular fluid protein carbonyl as a biomarker of oxidative stress in… Tawfik 2019 · Tawfik Maie S., Abdel-Ghaffar Khaled A., et al. · Journal of Liposome Research DOI:10.1080/08982104.2019.1566243 | 2019 | 1 | none stated | not extracted yet |
| A randomized, double-blind, placebo-controlled multicenter study for evaluating the effects of fixed-dose combinations of vitamin C, vitamin E,… Hong 2019 · Hong Ji-Youn, Lee Jung-Seok, et al. · BMC Oral Health DOI:10.1186/s12903-019-0728-2 | 2019 | 1 | none stated | not extracted yet |
| Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial Seydanur 2019 · Seydanur Dengizek Eltas, Serkan Dundar, et al. · Journal of Applied Oral Science DOI:10.1590/1678-7757-2018-0108 | 2019 | 1 | none stated | not extracted yet |
| <p>The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with… Javid 2019 · Zare Javid Ahmad, Bazyar Hadi, et al. · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy DOI:10.2147/dmso.s214333 | 2019 | 1 | none stated | not extracted yet |
| Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial Theodoro 2019 · Theodoro L.H., Cláudio M.M., et al. · Beneficial Microbes DOI:10.3920/bm2018.0150 | 2019 | 1 | none stated | not extracted yet |