Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta-Analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| <scp>FGFR1</scp> is an important prognostic factor in oral leukoplakia and tongue squamous cell carcinoma Mariz 2023 · Mariz Bruno Augusto Linhares Almeida, Sales de Sá Raísa, et al. · Journal of Oral Pathology & Medicine DOI:10.1111/jop.13398 | 2023 | 1 | none stated | not extracted yet |
| The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia Wils 2023 · Wils Leon J., Poell Jos B., et al. · Journal of Oral Pathology & Medicine DOI:10.1111/jop.13483 | 2023 | 1 | none stated | not extracted yet |
| Implication of TIPE2 Expression on the Malignant Transformation of Oral Leukoplakia Chen 2023 · CHEN HAIYUE, PEI MEILING, et al. · Anticancer Research DOI:10.21873/anticanres.16691 | 2023 | 1 | none stated | not extracted yet |
| Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders de Villalaín 2023 · de Villalaín Lucas, Álvarez-Teijeiro Saúl, et al. · International Journal of Molecular Sciences DOI:10.3390/ijms241814382 | 2023 | 1 | none stated | not extracted yet |
| Significance of nuclear <scp>EGFR</scp> and <scp>ABCG2</scp> expression in malignant transformation of oral potentially malignant disorders Tarle 2022 · Tarle Marko, Müller Danko, et al. · Head & Neck DOI:10.1002/hed.27174 | 2022 | 1 | none stated | not extracted yet |
| Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma Xu 2023 · Xu Shuang‐Bo, Wang Meng‐Yao, et al. · Oral Diseases DOI:10.1111/odi.14332 | 2022 | 1 | none stated | not extracted yet |
| Podoplanin Expression Independently and Jointly with Oral Epithelial Dysplasia Grade Acts as a Potential Biomarker of Malignant Transformation in… Monteiro 2022 · Monteiro Luís, do Amaral Barbas, et al. · Biomolecules DOI:10.3390/biom12050606 | 2022 | 1 | none stated | not extracted yet |
| Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A… Yagyuu 2021 · Yagyuu Takahiro, Funayama Naoki, et al. · PLOS ONE DOI:10.1371/journal.pone.0250359 | 2021 | 1 | none stated | not extracted yet |
| Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral… Monteiro 2021 · Monteiro L, Silva P, et al. · Medicina oral, patologia oral y cirugia bucal PMID:34704983 | 2021 | 1 | none stated | not extracted yet |
| FOXP3 lymphocyte status may predict the risk of malignant transformation in oral leukoplakia Sakata 2020 · Sakata Junki, Yoshida Ryoji, et al. · Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology DOI:10.1016/j.ajoms.2019.06.005 | 2020 | 1 | none stated | not extracted yet |
| Importance of Ki-67 Labeling in Oral Leukoplakia with Features of Dysplasia and Carcinomatous Transformation: An Observational Study over 4 Years Mondal 2020 · Mondal Krishnendu, Mandal Rupali, et al. · South Asian Journal of Cancer DOI:10.1055/s-0040-1721212 | 2020 | 1 | none stated | not extracted yet |
| Intraepithelial CD163<sup>+</sup> macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening Shigeoka 2020 · Shigeoka Manabu, Koma Yu‐ichiro, et al. · Oral Diseases DOI:10.1111/odi.13269 | 2020 | 1 | none stated | not extracted yet |
| Malignant transformation of oral leukoplakia is associated with macrophage polarization Weber 2020 · Weber Manuel, Wehrhan Falk, et al. · Journal of Translational Medicine DOI:10.1186/s12967-019-02191-0 | 2020 | 1 | none stated | not extracted yet |
| DEC1: a potential biomarker of malignant transformation in oral leukoplakia Mao 2020 · MAO Ting, XIONG Haofeng, et al. · Brazilian Oral Research DOI:10.1590/1807-3107bor-2020.vol34.0052 | 2020 | 1 | none stated | not extracted yet |
| <p><em>PTHLH</em> Predicts the Prognosis of Patients with Oral Leukoplakia</p> Lv 2020 · Lv Zhongjing, Cong Rong, et al. · OncoTargets and Therapy DOI:10.2147/ott.s261124 | 2020 | 1 | none stated | not extracted yet |
| Role of the human papillomavirus in malignant transformation of oral leukoplakia distinct from oropharyngeal squamous cell carcinoma: A study of 76… Wu 2019 · Wu Wenyan, Wang Zhen, et al. · Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology DOI:10.1016/j.oooo.2019.01.004 | 2019 | 1 | none stated | not extracted yet |
| Combined Testing of p16 Tumour-suppressor Protein and Human Papillomavirus in Patients With Oral Leukoplakia and Oral Squamous Cell Carcinoma Sundberg 2019 · SUNDBERG JONAS, KORYTOWSKA MAGDALENA, et al. · Anticancer Research DOI:10.21873/anticanres.13241 | 2019 | 1 | none stated | not extracted yet |
| The Emerging Role of NANOG as an Early Cancer Risk Biomarker in Patients with Oral Potentially Malignant Disorders de Vicente 2019b · de Vicente Juan C., Rodríguez-Santamarta Tania, et al. · Journal of Clinical Medicine DOI:10.3390/jcm8091376 | 2019 | 1 | none stated | not extracted yet |
| SOX2 Expression Is an Independent Predictor of Oral Cancer Progression de Vicente 2019a · de Vicente Juan C., Donate-Pérez del Molino Paula, et al. · Journal of Clinical Medicine DOI:10.3390/jcm8101744 | 2019 | 1 | none stated | not extracted yet |
| Immunohistochemical Expression of Podoplanin in Clinical Variants of Oral Leukoplakia and Its Correlation With Epithelial Dysplasia D’Souza 2018 · D’souza Brendan, Nayak Ramakant, et al. · Applied Immunohistochemistry & Molecular Morphology DOI:10.1097/pai.0000000000000383 | 2018 | 1 | none stated | not extracted yet |
| Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation Zhu 2018 · Zhu Minwen, Liu Wei, et al. · Oncology Letters DOI:10.3892/ol.2018.8574 | 2018 | 1 | none stated | not extracted yet |
| Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma Ding 2018 · Ding Xu, Zheng Yang, et al. · Oncology Reports DOI:10.3892/or.2018.6335 | 2018 | 1 | none stated | not extracted yet |
| Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia Sakata 2017 · Sakata Junki, Yoshida Ryoji, et al. · Cancer Medicine DOI:10.1002/cam4.1005 | 2017 | 1 | none stated | not extracted yet |
| Nomogram for risk prediction of malignant transformation in oral leukoplakia patients using combined biomarkers Zhang 2017a · Zhang Xianglan, Kim Ki-Yeol, et al. · Oral Oncology DOI:10.1016/j.oraloncology.2017.07.015 | 2017 | 1 | none stated | not extracted yet |
| Snail and Axin2 expression predict the malignant transformation of oral leukoplakia Zhang 2017b · Zhang Xianglan, Kim Ki-Yeol, et al. · Oral Oncology DOI:10.1016/j.oraloncology.2017.08.004 | 2017 | 1 | none stated | not extracted yet |
| Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer Saintigny 2018 · Saintigny Pierre, William William N, et al. · JNCI: Journal of the National Cancer Institute DOI:10.1093/jnci/djx186 | 2017 | 1 | none stated | not extracted yet |
| HERG1 potassium channel expression in potentially malignant disorders of the oral mucosa and prognostic relevance in oral squamous cell carcinoma Fernández-Valle 2016b · Fernández–Valle Álvaro, Rodrigo Juan Pablo, et al. · Head & Neck DOI:10.1002/hed.24493 | 2016 | 1 | none stated | not extracted yet |
| c-Jun, pc-Jun, and p27 are differently expressed in oral leukoplakias in smokers and never-smokers Lima 2016 · Lima Joelma Sousa, Correa Luciana, et al. · Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology DOI:10.1016/j.oooo.2015.09.003 | 2016 | 1 | none stated | not extracted yet |
| Expression of the voltage‐gated potassium channel Kv3.4 in oral leucoplakias and oral squamous cell carcinomas Fernández-Valle 2016a · Fernández‐Valle Álvaro, Rodrigo Juan Pablo, et al. · Histopathology DOI:10.1111/his.12917 | 2016 | 1 | none stated | not extracted yet |
| <scp>LAMC</scp>2 is a predictive marker for the malignant progression of leukoplakia Nguyen 2017 · Nguyen Chi Thi Kim, Okamura Takeshi, et al. · Journal of Oral Pathology & Medicine DOI:10.1111/jop.12485 | 2016 | 1 | none stated | not extracted yet |
| ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia Habiba 2017 · Habiba Umma, Hida Kyoko, et al. · Oncology Letters DOI:10.3892/ol.2016.5379 | 2016 | 1 | none stated | not extracted yet |
| Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant… Nayak 2015 · Nayak Seema, Goel Madhu Mati, et al. · PLOS ONE DOI:10.1371/journal.pone.0138801 | 2015 | 1 | none stated | not extracted yet |
| Predictive Role of p53 Protein as a Single Marker or Associated with ki67 Antigen in Oral Leukoplakia: A Retrospective Longitudinal Study Gissi 2015 · Gissi Davide B, Gabusi Andrea, et al. · The Open Dentistry Journal DOI:10.2174/1874210601509010041 | 2015 | 1 | none stated | not extracted yet |
| S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia Kaur 2014 · Kaur Jatinder, Matta Ajay, et al. · International Journal of Cancer DOI:10.1002/ijc.28473 | 2013 | 1 | none stated | not extracted yet |
| Podoplanin expression in oral leukoplakia: Tumorigenic role de Vicente 2013 · de Vicente Juan Carlos, Rodrigo Juan Pablo, et al. · Oral Oncology DOI:10.1016/j.oraloncology.2013.02.008 | 2013 | 1 | none stated | not extracted yet |
| Molecular screening of oral precancer Graveland 2013 · Graveland A. Peggy, Bremmer Jantine F., et al. · Oral Oncology DOI:10.1016/j.oraloncology.2013.09.005 | 2013 | 1 | none stated | not extracted yet |
| The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral Leukoplakia Xia 2013 · Xia Rong-Hui, Song Xiao-Meng, et al. · PLoS ONE DOI:10.1371/journal.pone.0066794 | 2013 | 1 | none stated | not extracted yet |
| The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia Ries 2013 · RIES JUTTA, VAIRAKTARIS ELEFTHERIOS, et al. · Oncology Reports DOI:10.3892/or.2013.2545 | 2013 | 1 | none stated | not extracted yet |
| Expression patterns of cancer stem cell markers ALDH1 and CD133 correlate with a high risk of malignant transformation of oral leukoplakia Liu 2012b · Liu Wei, Wu Lan, et al. · International Journal of Cancer DOI:10.1002/ijc.27720 | 2012 | 1 | none stated | not extracted yet |
| Podoplanin expression in oral leukoplakia: prognostic value and clinicopathological implications Kreppel 2012 · Kreppel M, Kreppel B, et al. · Oral Diseases DOI:10.1111/j.1601-0825.2012.01927.x | 2012 | 1 | none stated | not extracted yet |
| Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia Ries 2012 · Ries Jutta, Agaimy Abbas, et al. · Cancer Investigation DOI:10.3109/07357907.2012.691191 | 2012 | 1 | none stated | not extracted yet |
| Two stem cell markers, ATP‐binding cassette, G2 subfamily (ABCG2) and BMI‐1, predict the transformation of oral leukoplakia to cancer Liu 2012a · Liu Wei, Feng Jin‐Qiu, et al. · Cancer DOI:10.1002/cncr.26483 | 2011 | 1 | none stated | not extracted yet |
| EZH2 Promotes Malignant Phenotypes and Is a Predictor of Oral Cancer Development in Patients with Oral Leukoplakia Cao 2011 · Cao Wei, Younis Rania H., et al. · Cancer Prevention Research DOI:10.1158/1940-6207.capr-11-0130 | 2011 | 1 | none stated | not extracted yet |
| Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma Matsubara 2011 · Kawano Shintaro · International Journal of Oncology DOI:10.3892/ijo.2011.1151 | 2011 | 1 | none stated | not extracted yet |
| Epidermal Growth Factor Receptor Expression and Gene Copy Number in the Risk of Oral Cancer Benchekroun 2010 · Taoudi Benchekroun Mohammed, Saintigny Pierre, et al. · Cancer Prevention Research DOI:10.1158/1940-6207.capr-09-0163 | 2010 | 1 | none stated | not extracted yet |
| Role of TP53 in the progression of pre‐malignant and malignant oral mucosal lesions. A follow‐up study of 144 patients Ögmundsdóttir 2009 · Ögmundsdóttir H. M., Björnsson J., et al. · Journal of Oral Pathology & Medicine DOI:10.1111/j.1600-0714.2009.00766.x | 2009 | 1 | none stated | not extracted yet |
| ΔNp63 Overexpression, Alone and in Combination with Other Biomarkers, Predicts the Development of Oral Cancer in Patients with Leukoplakia Saintigny 2009 · Saintigny Pierre, El-Naggar Adel K., et al. · Clinical Cancer Research DOI:10.1158/1078-0432.ccr-09-0498 | 2009 | 1 | none stated | not extracted yet |
| Keratin 8 expression in head and neck epithelia Matthias 2008 · Matthias Christoph, Mack Brigitte, et al. · BMC Cancer DOI:10.1186/1471-2407-8-267 | 2008 | 1 | none stated | not extracted yet |
| Podoplanin: A Novel Marker for Oral Cancer Risk in Patients With Oral Premalignancy Kawaguchi 2008 · Kawaguchi Hidetoshi, El-Naggar Adel K., et al. · Journal of Clinical Oncology DOI:10.1200/jco.2007.13.4072 | 2008 | 1 | none stated | not extracted yet |
| Alterations of Rb Pathway Components Are Frequent Events in Patients with Oral Epithelial Dysplasia and Predict Clinical Outcome in Patients with… Soni 2005 · Soni Shilpi, Kaur Jatinder, et al. · Oncology DOI:10.1159/000086970 | 2005 | 1 | none stated | not extracted yet |