Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Uysal 2010 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Welk 2020 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Probiotics for maintaining oral health during fixed orthodontic treatment: A systematic review and meta-analysis. Simon 2022 · Robin Vincken, Wim Teughels, et al. · International journal of dental hygiene PMID:38764155 | 2025 | 1 | none stated | not extracted yet |
| Topographic Evaluation of the Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions: An In Vitro Study. Singh 2016 · Soliman Eman M, Abdelfattah Wegdan M, et al. · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] PMID:39663737 | 2025 | 1 | none stated | not extracted yet |
| Remineralization potential of strontium-doped nano-hydroxyapatite dentifrice and casein phosphopeptide-amorphous calcium phosphate cream on white… Karabekiroğlu 2017 · Rajendran Ratheesh, Antony S Delphine Priscilla, et al. · SAGE open medicine PMID:38162913 | 2024 | 1 | none stated | not extracted yet |
| Supragingival dental biofilm profile and biofilm control during orthodontic treatment with fixed orthodontic appliance: A randomized controlled trial. Vivaldi-Rodrigues 2006 · Zibar Belasic T, Badnjevic M, et al. · Archives of oral biology PMID:38701663 | 2024 | 1 | none stated | not extracted yet |
| The effect of nano-hydroxyapatite on white spot lesions: A systematic review and meta-analysis. Tomaževič 2022 · Alajlan S, A Baysan · Journal of dentistry PMID:39395626 | 2024 | 1 | none stated | not extracted yet |
| Antimicrobial efficacy and bonding properties of orthodontic bonding systems enhanced with silver nanoparticles: a systematic review with… Raghis 2018 · Sycińska-Dziarnowska Magdalena, Szyszka-Sommerfeld Liliana, et al. · BMC oral health PMID:39501230 | 2024 | 1 | none stated | not extracted yet |
| Comparative Evaluation of White Spot Lesion incidence between NovaMin, Probiotic, And Fluoride containing Dentifrices during Orthodontic treatment… Tiwari 2023 · Tiwari Akriti, Jain Ravindra Kumar · Clinical and Investigative Orthodontics DOI:10.1080/27705781.2023.2190950 | 2023 | 1 | none stated | not extracted yet |
| Effect of calcium fluoride nanoparticles in prevention of demineralization during orthodontic fixed appliance treatment: a randomized clinical trial. Al Tuma 2023 · Al Tuma Rawof R, Yassir Yassir A · European journal of orthodontics PMID:36049047 | 2023 | 1 | none stated | not extracted yet |
| Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review. Du 2012 · Sonesson Mikael, Twetman Svante · European journal of orthodontics PMID:37032523 | 2023 | 1 | none stated | not extracted yet |
| Comparative evaluation of four treatments for postorthodontic white spot lesions: a randomized controlled trial. Wang 2023 RCT · Wang Qiqiu, Zhou Yang, et al. · Clinical oral investigations PMID:37603170 | 2023 | 1 | none stated | not extracted yet |
| Effectiveness of amine fluoride mouthwash in preventing white spot lesions during fixed orthodontic therapy - A randomized control trial. Bailey 2009 · Ravi Kiran K R, Sabrish Sharanya, et al. · Indian journal of dental research : official publication of Indian Society for Dental Research PMID:38197343 | 2023 | 1 | none stated | not extracted yet |
| Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis. Kiran 2023 · Gianola Silvia, Bargeri Silvia, et al. · British journal of sports medicine PMID:33849907 | 2022 | 1 | none stated | not extracted yet |
| An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the… Jahanbin 2016 · Pilli Lakshmi Narayana, Singaraju Gowri Sankar, et al. · BioMed research international PMID:35355827 | 2022 | 1 | none stated | not extracted yet |
| DIAGNOdent pen quantification of the synergy of NovaMin® in fluoride toothpaste to remineralize white spot lesions in patients with fixed… Mollabashi 2022 · Mollabashi Vahid, Heydarpour Maryam, et al. · International orthodontics PMID:35428577 | 2022 | 1 | none stated | not extracted yet |
| Remineralization of early enamel caries lesions using self-assembling peptides P11-4: Systematic review and meta-analysis. Beerens 2010 · B K Aparna, R Yashoda, et al. · Journal of oral biology and craniofacial research PMID:35433245 | 2022 | 1 | none stated | not extracted yet |
| Effect of nanomicelle curcumin-based photodynamic therapy on the dynamics of white spot lesions and virulence of Streptococcus mutans in patients… O’Reilly 2013 · Hosseinpour-Nader Armin, Karimi Narges, et al. · Photodiagnosis and photodynamic therapy PMID:36602066 | 2022 | 1 | none stated | not extracted yet |
| Prevention of non-cavitated lesions with fluoride and xylitol varnishes during orthodontic treatment: a randomized clinical trial. Mahmoudzadeh 2019 · Silva Vinicius Merino, Massaro Camila, et al. · Clinical oral investigations PMID:33835256 | 2021 | 1 | none stated | not extracted yet |
| Efficacy of resin infiltration to mask post-orthodontic or non-post-orthodontic white spot lesions or fluorosis - a systematic review and… Hosseinpour-Nader 2022 · Bourouni S, Dritsas K, et al. · Clinical oral investigations PMID:34106348 | 2021 | 1 | none stated | not extracted yet |
| Effect of fluoride dentifrices on white spot lesions during orthodontic treatment: A randomized trial. Hammad 2016 · Kau Chung H, Wang Jue, et al. · The Angle orthodontist PMID:30719933 | 2019 | 1 | none stated | not extracted yet |
| Efficacy of Amorphous Calcium Phosphate (ACP) Containing Adhesive in Preventing Demineralization during Orthodontic Treatment, a Triple Blinded… Mehta 2015 · Alshammari Fahad Mohammed, Sanea Jamal Al · The journal of contemporary dental practice PMID:31358717 | 2019 | 1 | none stated | not extracted yet |
| Efficacy of CPP-ACP and CPP-ACPF for Prevention and Remineralization of White Spot Lesions in Orthodontic Patients: a Systematic Review of… Beerens 2018 · Imani Mohammad Moslem, Safaei Mohsen, et al. · Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH PMID:31762578 | 2019 | 1 | none stated | not extracted yet |
| Comparative assessment of conventional and light-curable fluoride varnish in the prevention of enamel demineralization during fixed appliance… Shah 2017 · Shah Mandar, Paramshivam Ganesh, et al. · European journal of orthodontics PMID:28505317 | 2018 | 1 | none stated | not extracted yet |
| Changes in white spot lesions following post-orthodontic weekly application of 1.25 per cent fluoride gel over 6 months-a randomized… Belasic 2024 · Bock Niko C, Seibold Laura, et al. · European journal of orthodontics PMID:27702807 | 2017 | 1 | none stated | not extracted yet |
| Efficacy of fluoride varnish for preventing white spot lesions and gingivitis during orthodontic treatment with fixed appliances-a prospective… Najafi 2022 · Kirschneck Christian, Christl Jan-Joachim, et al. · Clinical oral investigations PMID:26832780 | 2016 | 1 | none stated | not extracted yet |
| Control of White Spot Lesions with Use of Fluoride Varnish or Chlorhexidine Gel During Orthodontic Treatment A Randomized Clinical Trial. Kaveh 2022 · Restrepo M, Bussaneli D G, et al. · The Journal of clinical pediatric dentistry PMID:27471804 | 2016 | 1 | none stated | not extracted yet |
| Efficacy of resin-modified glass ionomer cement varnish in the prevention of white spot lesions during comprehensive orthodontic treatment: a… Uysal 2010 · Kumar Jena Ashok, Pal Singh Satinder, et al. · Journal of orthodontics PMID:25843603 | 2015 | 1 | none stated | not extracted yet |
| Effect of light-curable fluoride varnish on enamel demineralization adjacent to orthodontic brackets: an in-vivo study. Trimpeneers 1996 · Mehta Anurag, Paramshivam Ganesh, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:26522042 | 2015 | 1 | none stated | not extracted yet |
| Evaluation of 3 commercially available materials for resolution of white spot lesions. Jena 2015 · Ballard Richard W, Hagan Joseph L, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:23540640 | 2013 | 1 | none stated | not extracted yet |
| Effectiveness of a sealant compared with no sealant in preventing enamel demineralization in patients with fixed orthodontic appliances: a… Benson 2019 · O'Reilly Maria T, De Jesús Viñas Jaime, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:23726334 | 2013 | 1 | none stated | not extracted yet |
| Does a chitosan-containing dentifrice prevent demineralization around orthodontic brackets? Pilli 2022 · Uysal Tancan, Akkurt Meltem Derya, et al. · The Angle orthodontist PMID:21208086 | 2011 | 1 | none stated | not extracted yet |
| Effect of antibacterial monomer-containing adhesive on enamel demineralization around orthodontic brackets: an in-vivo study. Bock 2016 · Uysal Tancan, Amasyali Mihri, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:21536208 | 2011 | 1 | none stated | not extracted yet |
| Effect of fluoridated chewing sticks (Miswaks) on white spot lesions in postorthodontic patients. Flynn 2022 · Baeshen Hosam A, Lingström Peter, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:21889073 | 2011 | 1 | none stated | not extracted yet |
| In vivo effects of amorphous calcium phosphate-containing orthodontic composite on enamel demineralization around orthodontic brackets. van der Kaaij 2015 · Uysal T, Amasyali M, et al. · Australian dental journal PMID:20887516 | 2010 | 1 | none stated | not extracted yet |
| A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and… He 2016 · Øgaard B, Alm A Afzelius, et al. · European journal of orthodontics PMID:16230329 | 2006 | 1 | none stated | not extracted yet |
| The effects of argon laser curing of a resin adhesive on bracket retention and enamel decalcification: a prospective clinical trial. Kirschneck 2016 · Elaut J, Wehrbein H · European journal of orthodontics PMID:15536845 | 2004 | 1 | none stated | not extracted yet |
| A clinical evaluation of the effectiveness of a fluoride-releasing visible light-activated bonding system to reduce demineralization around… Kannan 2023 · Trimpeneers L M, Dermaut L R · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:8760850 | 1996 | 1 | none stated | not extracted yet |
| Badiee 2020 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Baeshen 2011 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Belasic 2024 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Benham 2009 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Bock 2016 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Enerbäck 2023 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Flynn 2022 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Øgaard 2005 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Garry 2017 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Gizani 2016 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Gohar 2022 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |
| Grocholewicz 2022 matched by author and year (probable) | NR | 1 | none stated | not extracted yet |