evidencegaps
Primary study · included by 2 reviews

Effect of intracanal cryotherapy on the inflammatory cytokine, proteolytic enzyme levels and post-operative pain in teeth with asymptomatic apical periodontitis: A randomized clinical trial.

Keskin 2023 · Keskin C, Aksoy A, Kalyoncuoğlu E, et al. · International endodontic journal · 2023

Included by

Effectiveness of intracanal cryotherapy in reducing post-endodontic pain in irreversible pulpitis: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Keskin 2023 · Table 2; References 7, 13-22

The review does not say which of its outcomes this study informs.

Cryotherapy as an adjunct in root canal therapy: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Keskin 2023 · Table 1; Results text and Figs. 2-6
Outcome this study informsPooled effectEvidenceCertainty
Postoperative pain intensity (VAS/NRS)
Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature · 24 h
SMD -0.58 [-0.89, -0.27]11 studies · 700 participantsHigh
Postoperative pain intensity (VAS/NRS)
Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature · 6 h
SMD -0.75 [-1.15, -0.35]9 studies · 621 participantsHigh

2 including reviews in total.