Primary study · included by 1 review
Impact of systemic probiotics as adjuncts to subgingival instrumentation on the oral-gut microbiota associated with periodontitis: A randomized controlled clinical trial.
De Oliveira et al. 2021 · de Oliveira Adriana Miranda, Lourenço Talita Gomes Baêta, Colombo Ana Paula Vieira · Journal of periodontology · 2022
PubMed 34028826doi:10.1002/jper.21-0078Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Trial PICO
Not extracted yet. Trial-level population, intervention, comparator, outcomes and design will appear here after the trial extraction run. Until then, the reviews below describe the study.
Results
Not extracted yet. Per-trial results (events, means, effect and weight as each review's forest plot reports them) will appear here after the trial extraction run.
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
Noticeable impact of gene sequencing on diagnosing/managing oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) | RR 0.50 [0.46, 0.54] | 8 studies · 2211 participants | Ungraded |
Noticeable impact of gene sequencing on diagnosing/managing oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) | OR 0.30 [0.26, 0.33] | 8 studies · 2211 participants | Ungraded |
Reduction in occurrence of oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) | RD -0.29 [-0.32, -0.26] | 8 studies · 2211 participants | Ungraded |
1 including review in total.