evidencegaps
Primary study · included by 1 review

Bioactivation Treatment with Mixed Acid and Heat on Titanium Implants Fabricated by Selective Laser Melting Enhances Preosteoblast Cell Differentiation.

Le 2021 · Le Phuc Thi Minh, Shintani Seine A, Takadama Hiroaki, et al. · Nanomaterials (Basel, Switzerland) · 2021

Included by

Specific gene expression patterns associated as reliable biomarkers for predicting dental implant successful osseointegration: a literature review and focused meta-analysis.
Non-Cochrane · other · 2025 · cited as Le 2021 · Table 2; Figure 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
RUNX2 gene expression (relative expression)
Modified titanium implant surface vs Control (unmodified) titanium surface
SMD 5.38 [0.66, 10.1]4 studies · 32 participantsLow
RUNX2 gene expression (relative expression)
Modified titanium implant surface vs Control (unmodified) titanium surface
SMD 2.58 [1.21, 3.95]NRGRADE not reported
Upregulation of pro-osteogenic markers (RUNX2)
Modified implant surface vs Control surface
Not applicable (13 primary studies, including 6 in vitro studies in meta-analysis); LOW13 studiesLow

1 including review in total.