Primary study · included by 1 review

Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene.

Van et al. 2019 · van Rooij Iris Alm, Ludwig Kerstin U, Welzenbach Julia, et al. · Genes · 2019

PubMed 31817908 doi:10.3390/genes10121023Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Trial PICO

Not extracted yet. Trial-level population, intervention, comparator, outcomes and design will appear here after the trial extraction run. Until then, the reviews below describe the study.

Results

Not extracted yet. Per-trial results (events, means, effect and weight as each review's forest plot reports them) will appear here after the trial extraction run.

Included by

Gene sequencing applications to combat oral-cavity related disorders: a systematic review with meta-analysis.

Non-Cochrane · prognostic · 2024 · cited as Van et al. 2019 · Table 1 [69]; Figs. 3 (non-significant) and 4 (meta-analysis); GWAS cleft lip; ref 69 (van Rooij, Genes 2019)

Outcome this study informs	Pooled effect	Evidence	Certainty
Noticeable impact of gene sequencing on diagnosing/managing oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots)	RR 0.50 [0.46, 0.54]	8 studies · 2211 participants	Ungraded
Noticeable impact of gene sequencing on diagnosing/managing oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots)	OR 0.30 [0.26, 0.33]	8 studies · 2211 participants	Ungraded
Reduction in occurrence of oral conditions Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots)	RD -0.29 [-0.32, -0.26]	8 studies · 2211 participants	Ungraded

1 including review in total.