evidencegaps
Primary study · included by 2 reviews

Pain and quality of life after endodontic surgery with or without advanced platelet-rich fibrin membrane application: a randomized clinical trial.

Soto-Peñaloza 2020 · Soto-Peñaloza David, Peñarrocha-Diago Miguel, Cervera-Ballester Juan, et al. · Clinical oral investigations · 2020

Included by

Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Soto-Penaloza 2020 · Table 2; Table 3; Figure 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
Early postoperative pain (VAS)
Platelet-rich fibrin or its derivatives (L-PRF, A-PRF, A-PRF+, i-PRF, PRF membrane) as adjunct to endodontic microsurgery vs Endodontic microsurgery without PRF (conventional surgery/control) · First postoperative week
SMD -0.617 [-1.026, -0.208]3 studies · 120 participantsModerate
Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Soto-Peñaloza 2020 · Table 1; reference 20
Outcome this study informsPooled effectEvidenceCertainty
Postoperative pain (VAS)
Adjunctive autologous platelet concentrate (PRP, PRF, A-PRF+) in the surgical defect vs Conventional periapical surgery without platelet concentrate · First postoperative week (7 days)
MD -3.96 [-9.36, 1.44]2 studies · 70 participantsModerate

2 including reviews in total.