Primary study · included by 2 reviews

Evaluation of Blood Clot, Platelet-rich Plasma, Platelet-rich Fibrin, and Platelet Pellet as Scaffolds in Regenerative Endodontic Treatment: A Prospective Randomized Trial.

Ulusoy 2019 · Ulusoy Ayca Tuba, Turedi Irem, Cimen Muge, et al. · Journal of endodontics · 2019

Included by

Efficacy of White Mineral Trioxide Aggregate in Regenerative Endodontic Procedures and Apexification for Immature Permanent Teeth: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Ulusoy 2019 · Table 1; References; Fig. 3-5

Outcome this study informs	Pooled effect	Evidence	Certainty
Radiographic success Platelet concentrate scaffold (PRP, PRF or PP) with WMTA in regenerative endodontic procedures vs Blood clot scaffold with WMTA	OR 7.49 [1.16, 48.22]	2 studies · 69 participants	GRADE not reported
Radiographic success WMTA as apical plug (apexification) or coronal barrier in regenerative endodontic procedures, single-arm vs None (single-arm pooled proportion)	Proportion 0.98 [0.88, 1.00]	2 studies · 32 participants	GRADE not reported
Radiographic success WMTA as apical plug (apexification) or coronal barrier in regenerative endodontic procedures, single-arm vs None (single-arm pooled proportion)	Proportion 0.99 [0.96, 1.00]	6 studies · 112 participants	Very low
Radiographic success WMTA as apical plug (apexification) or coronal barrier in regenerative endodontic procedures vs None (single-arm proportion)	Proportion 0.96 [0.90, 0.99]	6 studies · 112 participants	Very low
Clinical success WMTA coronal barrier in regenerative endodontic procedures vs Alternative bioceramic cements (Totalfill putty, Biodentine)	OR 0.18 [0.02, 1.68]	2 studies · 67 participants	Moderate
Radiographic success Platelet concentrate scaffold (PRP, PRF or PP) with WMTA in regenerative endodontic procedures vs Blood clot scaffold with WMTA	OR 3.56 [0.87, 14.52]	4 studies · 145 participants	Very low
Radiographic success WMTA coronal barrier with platelet-rich plasma (PRP) scaffold in REP vs None (single-arm proportion)	Proportion 0.98 [0.87, 1.00]	2 studies · 33 participants	GRADE not reported

Also linked to PM42160814-P4-O1, PM42160814-P5-O1, which does not match a current question in this review.

Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Ulusoy 2019 · Table 1; reference 11

Outcome this study informs	Pooled effect	Evidence	Certainty
Periapical healing (radiographic success) Autologous platelet concentrates (PRP, PRF, platelet pellet) as REP scaffold vs Blood clot scaffold (induced bleeding) · 12 to 28 months follow-up	RD 0.04 [-0.08, 0.16]	3 studies · 236 participants	Very low

2 including reviews in total.