Primary study · included by 2 reviews

Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.

Iwasaki et al. 2019 · Iwasaki Masanori, Kimura Yumi, Ogawa Hiroshi, et al. · Journal of periodontal research · 2019

Included by

Outcome this study informsPooled effectEvidenceCertainty
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.45 [0.97, 2.16]11 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.52 [1.02, 2.28]12 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 2.21 [1.28, 3.81]6 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.17 [1.07, 1.28]6 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.02 [0.53, 1.96]2 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.17 [1.07, 1.28]5 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.49 [1.001, 2.22]3 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.20 [1.07, 1.34]2 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.49 [1.13, 1.97]14 studiesGRADE not reported
Periodontal diseases (periodontitis)
Overweight/obesity (BMI, waist circumference, WHR or neck circumference) vs Normal weight (no overweight/obesity)
OR 1.20 [0.63, 1.77]1 studyGRADE not reported
Association Between Periodontal Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis.
Non-Cochrane · aetiology · 2026 · cited as Iwasaki 2019 · Table 1; reference 26; Table 6
Outcome this study informsPooled effectEvidenceCertainty
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.11 [1.43, 3.12]3 studiesGRADE not reported
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.12 [1.51, 2.98]4 studies · 554 participantsGRADE not reported
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.21 [1.57, 3.12]4 studiesGRADE not reported
Cognitive impairment (cognitive decline, incident MCI, cognitive impairment)
Periodontitis (severe periodontitis by CDC/AAP criteria or radiographic bone loss) vs No periodontitis or less severe periodontitis · Cross-sectional to 5 years follow-up
RR 2.12 [1.51, 2.98]4 studies · 554 participantsGRADE not reported

2 including reviews in total.