Primary study · included by 1 review

Low-level laser therapy increases interleukin-1β in gingival crevicular fluid and enhances the rate of orthodontic tooth movement.

Varella 2018 · Varella Alissa Maria, Revankar Ameet V, Patil Anand K · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2018

Included by

The Effectiveness of Physical Adjunctive Interventions in the Acceleration of Orthodontic Tooth Movement: An Umbrella Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Varella 2018 · References 36-111; Supporting Information Tables S4-S6

Outcome this study informs	Pooled effect	Evidence	Certainty
Cumulative upper canine retraction from baseline (mm) Low-level laser therapy (LLLT) vs Standard orthodontic treatment without the adjunctive intervention · Month 2	MD 0.72 [0.18, 1.26]	9 studies · 240 participants	Low
Cumulative upper canine retraction from baseline (mm) Low-level laser therapy (LLLT) vs Standard orthodontic treatment without the adjunctive intervention · Month 1	MD 0.31 [0.13, 0.49]	14 studies · 354 participants	Low

1 including review in total.