evidencegaps
Primary study · included by 1 review

Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese.

Iwasaki et al. 2016 · Iwasaki M, Yoshihara A, Kimura Y, et al. · Journal of periodontal research · 2016

Included by

Association Between Periodontal Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis.
Non-Cochrane · aetiology · 2026 · cited as Iwasaki 2016 · Table 1; reference 23; Table 6
Outcome this study informsPooled effectEvidenceCertainty
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.11 [1.43, 3.12]3 studiesGRADE not reported
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.12 [1.51, 2.98]4 studies · 554 participantsGRADE not reported
Cognitive impairment or decline
Periodontitis vs Healthier periodontal status · Cross-sectional to 5 years
Generic RR 2.21 [1.57, 3.12]4 studiesGRADE not reported
Cognitive impairment (cognitive decline, incident MCI, cognitive impairment)
Periodontitis (severe periodontitis by CDC/AAP criteria or radiographic bone loss) vs No periodontitis or less severe periodontitis · Cross-sectional to 5 years follow-up
RR 2.12 [1.51, 2.98]4 studies · 554 participantsGRADE not reported

1 including review in total.