Primary study · included by 2 reviews

The impact of pathologic close margin on the survival of patients with early stage oral squamous cell carcinoma.

Chen 2012 · Chen Tseng-Cheng, Wang Cheng-Ping, Ko Jenq-Yuh, et al. · Oral oncology · 2012

Included by

Impact of surgical margins on recurrence and survival rate in patients with oral squamous cell carcinoma: A systematic review and meta-analysis.

Non-Cochrane · prognostic · 2026 · cited as Chen 2012 · Table 2; Figure 3a

Outcome this study informs	Pooled effect	Evidence	Certainty
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.657 [0.622, 0.694]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.658 [0.623, 0.695]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.654 [0.619, 0.691]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.696 [0.626, 0.773]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.657 [0.622, 0.694]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.657 [0.622, 0.694]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.656 [0.620, 0.693]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.640 [0.605, 0.677]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.658 [0.623, 0.695]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.634 [0.545, 0.738]	12 studies	Moderate
Overall survival (5-year) Positive surgical margins (mostly <5 mm; study definitions varied) vs Negative surgical margins (mostly 5 mm or more; one study 10 mm or more)	RR 0.656 [0.621, 0.693]	12 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.647 [0.612, 0.685]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.658 [0.623, 0.695]	11 studies	GRADE not reported
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years	RR 0.663 [0.628, 0.701]	11 studies	GRADE not reported

Prognostic value of surgical margin and margin to depth of invasion ratio in oral squamous cell carcinoma: a meta-analysis.

Non-Cochrane · prognostic · 2026 · cited as Chen 2012 · Table 1; References

The review does not say which of its outcomes this study informs.

2 including reviews in total.