Non-Cochrane · prognostic · PM42399960
Prognostic value of surgical margin and margin to depth of invasion ratio in oral squamous cell carcinoma: a meta-analysis.
Xu Jin, Cui Qian, Chen Yinqi, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-09103-x
Findings
32 findings
| Population | ||||
|---|---|---|---|---|
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Analysis source: multivariable analysis | HR 1.55 [1.11, 2.16] GRADE not reported 7 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Analysis source: Kaplan-Meier | HR 2.05 [1.25, 3.36] GRADE not reported 8 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Analysis source: univariate analysis | HR 1.81 [0.41, 8.04] GRADE not reported 2 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Analysis source: Kaplan-Meier | HR 1.70 [0.97, 2.97] GRADE not reported 5 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Cutoff: 1 mm | HR 3.01 [1.55, 5.85] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Region: Europe | HR 1.51 [0.85, 2.66] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Analysis source: univariate analysis | HR 1.80 [0.41, 7.98] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Analysis source: Kaplan-Meier | HR 1.80 [1.45, 2.25] GRADE not reported 9 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival | HR 1.99 [1.53, 2.58] GRADE not reported 21 studies · 7029 participants |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated with surgery | Poor (narrow or involved) surgical margin, at each study cutoff | Safe surgical margin (wider than the study cutoff) | Disease-free survival | HR 1.72 [1.29, 2.28] GRADE not reported 14 studies · 12401 participants |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Cutoff: 5 mm | HR 2.11 [1.48, 3.01] GRADE not reported 14 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Region: Asia | HR 1.61 [1.37, 1.90] GRADE not reported 16 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Cutoff: 5 mm | HR 1.72 [1.29, 2.28] GRADE not reported 14 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Region: North America | HR 1.39 [1.17, 1.64] GRADE not reported 6 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Cutoff: 5 mm | HR 1.59 [1.42, 1.78] GRADE not reported 26 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Region: Asia | HR 1.68 [1.21, 2.34] GRADE not reported 10 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Analysis source: multivariable analysis | HR 1.91 [1.22, 3.00] GRADE not reported 9 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Analysis source: multivariable analysis | HR 1.36 [1.19, 1.55] GRADE not reported 16 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Analysis source: univariate analysis | HR 1.99 [1.50, 2.64] GRADE not reported 4 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival | HR 1.56 [1.37, 1.77] GRADE not reported 28 studies · 57474 participants |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Overall survival Region: Europe | HR 1.41 [1.05, 1.88] GRADE not reported 5 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Region: North America | HR 5.79 [0.5, 67.06] GRADE not reported 2 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Disease-free survival Region: North America | HR 2.24 [0.71, 7.12] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Narrow or close surgical margin (below study-defined cutoff, mostly 5 mm) | Safe surgical margin (above the study-defined cutoff) | Recurrence-free survival Region: Asia | HR 1.93 [1.33, 2.79] GRADE not reported 14 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated with surgery | Low margin to depth of invasion ratio (MDR) | Safe MDR (above the study cutoff) | Disease-free survival MDR cutoff: 0.5 | HR 1.40 [1.12, 1.74] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Low margin to depth of invasion ratio (MDR, below study-defined cutoff such as 0.5) | Higher MDR (above the study-defined cutoff) | Disease-free survival Region: Asia | HR 1.40 [1.12, 1.74] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated with surgery | Low margin to depth of invasion ratio (MDR) | Safe MDR (above the study cutoff) | Disease-free survival Analysis source: multivariable analysis | HR 1.40 [1.12, 1.74] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Low margin to depth of invasion ratio (MDR, below study-defined cutoff such as 0.5) | Higher MDR (above the study-defined cutoff) | Overall survival MDR cutoff: 0.5 | HR 1.33 [1.17, 1.51] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated with surgery | Low margin to depth of invasion ratio (MDR) | Safe MDR (above the study cutoff) | Overall survival | HR 1.36 [1.21, 1.54] GRADE not reported 4 studies · 8195 participants |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Low margin to depth of invasion ratio (MDR, below study-defined cutoff such as 0.5) | Higher MDR (above the study-defined cutoff) | Overall survival Region: Asia | HR 1.36 [1.21, 1.54] GRADE not reported 4 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated surgically | Low margin to depth of invasion ratio (MDR, below study-defined cutoff such as 0.5) | Higher MDR (above the study-defined cutoff) | Overall survival Analysis source: multivariable analysis | HR 1.39 [1.23, 1.57] GRADE not reported 3 studies |
| Patients with pathologically diagnosed oral squamous cell carcinoma treated with surgery | Low margin to depth of invasion ratio (MDR) | Safe MDR (above the study cutoff) | Disease-free survival | HR 1.40 [1.12, 1.74] GRADE not reported 3 studies · 7773 participants |
Included primary studies 78
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Bajwa 2020 The relevance of surgical margins in clinically early oral squamous cell carcinoma. PMID:32711167 | 2020 | 1 other review | not stated | not extracted yet |
| Cariati 2019 What is the real prognostic value of close margins in oral oncology? PMID:31481249 | 2019 | 1 other review | not stated | not extracted yet |
| Chen 2012 The impact of pathologic close margin on the survival of patients with early stage oral squamous cell carcinoma. PMID:22349276 | 2012 | 1 other review | not stated | not extracted yet |
| Dillon 2015 How does the close surgical margin impact recurrence and survival when treating oral squamous cell carcinoma? PMID:25795179 | 2015 | 1 other review | not stated | not extracted yet |
| Lin 2021 Adequate surgical margins for oral cancer: A Taiwan cancer registry national database analysis. PMID:34049257 | 2021 | 1 other review | not stated | not extracted yet |
| Aziz 2024 ON THE EDGE: EVALUATING CLINICOPATHOLOGICAL OUTCOMES OF PATIENTS WITH CLOSE AND INVOLVED SURGICAL RESECTION MARGINS IN EARLY-STAGE TONGUE… DOI:10.53555/jptcp.v31i7.7201 | 2024 | this review only | not stated | not extracted yet |
| Bajwa 2020 The relevance of surgical margins in clinically early oral squamous cell carcinoma DOI:10.1016/j.oraloncology.2020.104913 | 2020 | this review only | not stated | not extracted yet |
| Bera 2023 Survival Outcomes and Factors Affecting Survival in Resectable Locally Advanced Oral Squamous Cell Carcinoma DOI:10.1007/s12070-022-03404-7 | 2022 | this review only | not stated | not extracted yet |
| Bera 2023 Survival Outcomes and Factors Affecting Survival in Resectable Locally Advanced Oral Squamous Cell Carcinoma. PMID:37275034 | 2023 | this review only | not stated | not extracted yet |
| Brinkman 2020 Impact of 3 mm margin on risk of recurrence and survival in oral cancer DOI:10.1016/j.oraloncology.2020.104883 | 2020 | this review only | not stated | not extracted yet |
| Brinkman 2020 Impact of 3 mm margin on risk of recurrence and survival in oral cancer. PMID:32659737 | 2020 | this review only | not stated | not extracted yet |
| Cariati 2019 What is the real prognostic value of close margins in oral oncology? DOI:10.1016/j.currproblcancer.2019.100500 | 2019 | this review only | not stated | not extracted yet |
| Chen 2012 The impact of pathologic close margin on the survival of patients with early stage oral squamous cell carcinoma DOI:10.1016/j.oraloncology.2012.01.015 | 2012 | this review only | not stated | not extracted yet |
| Chen 2019 Impact of dysplastic surgical margins for patients with oral squamous cell carcinoma DOI:10.1016/j.oraloncology.2019.07.015 | 2019 | this review only | not stated | not extracted yet |
| Chen 2019 Impact of dysplastic surgical margins for patients with oral squamous cell carcinoma. PMID:31421465 | 2019 | this review only | not stated | not extracted yet |
| Chiou 2010 Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence DOI:10.1186/1748-717x-5-79 | 2010 | this review only | not stated | not extracted yet |
| Chiou 2010 Buccal mucosa carcinoma: surgical margin less than 3 mm, not 5 mm, predicts locoregional recurrence. PMID:20840791 | 2010 | this review only | not stated | not extracted yet |
| Cho 2022 Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features. PMID:36316182 | 2022 | this review only | not stated | not extracted yet |
| Choi 2022 Analysis of prognostic factors through survival rate analysis of oral squamous cell carcinoma patients treated at the National Cancer… PMID:36316186 | 2022 | this review only | not stated | not extracted yet |
| Dillon 2015 How Does the Close Surgical Margin Impact Recurrence and Survival When Treating Oral Squamous Cell Carcinoma? DOI:10.1016/j.joms.2014.12.014 | 2015 | this review only | not stated | not extracted yet |
| Ding 2019 Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer DOI:10.1001/jamaoto.2018.2974 | 2019 | this review only | not stated | not extracted yet |
| Ding 2019 Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer. PMID:30452499 | 2019 | this review only | not stated | not extracted yet |
| Dudkiewicz 2024 Rethinking Surgical Margins: A New Approach to Predict Outcomes in Oral Squamous Cell Carcinoma. PMID:39230351 | 2025 | this review only | not stated | not extracted yet |
| Dudkiewicz 2025 Rethinking Surgical Margins: A New Approach to Predict Outcomes in Oral Squamous Cell Carcinoma DOI:10.1002/lary.31744 | 2024 | this review only | not stated | not extracted yet |
| Ebrahimi 2011 The prognostic and staging implications of bone invasion in oral squamous cell carcinoma DOI:10.1002/cncr.26032 | 2011 | this review only | not stated | not extracted yet |
| Ebrahimi 2011 The prognostic and staging implications of bone invasion in oral squamous cell carcinoma. PMID:21437887 | 2011 | this review only | not stated | not extracted yet |
| Fowler 2022 Surgical margins of the oral cavity: Is 5 mm really necessary? DOI:10.1186/s40463-022-00584-8 | 2022 | this review only | not stated | not extracted yet |
| Fowler 2022 Surgical margins of the oral cavity: is 5 mm really necessary? PMID:36195903 | 2022 | this review only | not stated | not extracted yet |
| Fridman 2018 The role of adjuvant treatment in early‐stage oral cavity squamous cell carcinoma: An international collaborative study DOI:10.1002/cncr.31531 | 2018 | this review only | not stated | not extracted yet |
| Fridman 2018 The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: An international collaborative study. PMID:29757457 | 2018 | this review only | not stated | not extracted yet |
| Hung 2024 Margin to depth of invasion ratio as an indicator for stratifying close margins in early-stage oral squamous cell carcinoma DOI:10.1016/j.oraloncology.2024.106726 | 2024 | this review only | not stated | not extracted yet |
| Hung 2024 Margin to depth of invasion ratio as an indicator for stratifying close margins in early-stage oral squamous cell carcinoma. PMID:38377691 | 2024 | this review only | not stated | not extracted yet |
| Hung 2025 Risk Classification of Oral Cancer Surgical Margins: Margin to Depth of Invasion Ratio Analysis DOI:10.1245/s10434-025-17286-w | 2025 | this review only | not stated | not extracted yet |
| Hung 2025 Risk Classification of Oral Cancer Surgical Margins: Margin to Depth of Invasion Ratio Analysis. PMID:40268847 | 2025 | this review only | not stated | not extracted yet |
| Iseli 2012 Are wider surgical margins needed for early oral tongue cancer? DOI:10.1017/s002221511100332x | 2012 | this review only | not stated | not extracted yet |
| Iseli 2012 Are wider surgical margins needed for early oral tongue cancer? PMID:22258616 | 2012 | this review only | not stated | not extracted yet |
| Jan 2011 Prognostic Factors in Patients With Buccal Squamous Cell Carcinoma: 10-Year Experience DOI:10.1016/j.joms.2010.05.017 | 2011 | this review only | not stated | not extracted yet |
| Jan 2011 Prognostic factors in patients with buccal squamous cell carcinoma: 10-year experience. PMID:21238843 | 2011 | this review only | not stated | not extracted yet |
| Jang 2017 Differential Impact of Close Surgical Margin on Local Recurrence According to Primary Tumor Size in Oral Squamous Cell Carcinoma DOI:10.1245/s10434-016-5497-4 | 2016 | this review only | not stated | not extracted yet |
| Jang 2017 Differential Impact of Close Surgical Margin on Local Recurrence According to Primary Tumor Size in Oral Squamous Cell Carcinoma. PMID:27519352 | 2017 | this review only | not stated | not extracted yet |
| Kamalakkannan 2024 Margin status, adjuvant treatment and recurrence in buccal cancer DOI:10.1016/j.oraloncology.2024.106927 | 2024 | this review only | not stated | not extracted yet |
| Kamalakkannan 2024 Margin status, adjuvant treatment and recurrence in buccal cancer. PMID:38943869 | 2024 | this review only | not stated | not extracted yet |
| Klibngern 2024 Margin-to-depth ratio as an independent prognostic factor in resected oral cavity squamous cell carcinoma: A nationwide cohort study DOI:10.1016/j.oraloncology.2024.107102 | 2024 | this review only | not stated | not extracted yet |
| Klibngern 2024 Margin-to-depth ratio as an independent prognostic factor in resected oral cavity squamous cell carcinoma: A nationwide cohort study. PMID:39488902 | 2024 | this review only | not stated | not extracted yet |
| Kohler 2022 The impact of worst pattern of invasion on the extension of surgical margins in oral squamous cell carcinoma. PMID:34904762 | 2022 | this review only | not stated | not extracted yet |
| Köhler 2022 The impact of worst pattern of invasion on the extension of surgical margins in oral squamous cell carcinoma DOI:10.1002/hed.26956 | 2021 | this review only | not stated | not extracted yet |
| Kurita 2010 Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma DOI:10.1016/j.oraloncology.2010.08.014 | 2010 | this review only | not stated | not extracted yet |
| Kurita 2010 Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma. PMID:20920879 | 2010 | this review only | not stated | not extracted yet |
| Lau 2021 Histopathologic prognostic indices in tongue squamous cell carcinoma DOI:10.1007/s00405-020-06329-5 | 2020 | this review only | not stated | not extracted yet |
| Lau 2021 Histopathologic prognostic indices in tongue squamous cell carcinoma. PMID:32897441 | 2021 | this review only | not stated | not extracted yet |
| Liao 2008 Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer DOI:10.1245/s10434-007-9761-5 | 2007 | this review only | not stated | not extracted yet |
| Liao 2008 Analysis of risk factors of predictive local tumor control in oral cavity cancer. PMID:18165878 | 2008 | this review only | not stated | not extracted yet |
| Lien 2020 Influence of Hyperglycemia on Treatment Outcomes of Oral Cavity Squamous Cell Carcinoma DOI:10.1016/j.joms.2020.01.018 | 2020 | this review only | not stated | not extracted yet |
| Lien 2020 Influence of Hyperglycemia on Treatment Outcomes of Oral Cavity Squamous Cell Carcinoma. PMID:32081693 | 2020 | this review only | not stated | not extracted yet |
| Lin 2021 Adequate surgical margins for oral cancer: A Taiwan cancer registry national database analysis DOI:10.1016/j.oraloncology.2021.105358 | 2021 | this review only | not stated | not extracted yet |
| Loree 1990 Significance of positive margins in oral cavity squamous carcinoma DOI:10.1016/s0002-9610(05)80555-0 | 1990 | this review only | not stated | not extracted yet |
| Loree 1990 Significance of positive margins in oral cavity squamous carcinoma. PMID:2221245 | 1990 | this review only | not stated | not extracted yet |
| Luryi 2015 Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer DOI:10.1001/jamaoto.2015.0719 | 2015 | this review only | not stated | not extracted yet |
| Luryi 2015 Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer: Analysis of 6830 Cases From the National Cancer Data Base. PMID:25974757 | 2015 | this review only | not stated | not extracted yet |
| Mishra 2019 Defining optimum surgical margins in buccoalveolar squamous cell carcinoma DOI:10.1016/j.ejso.2019.01.224 | 2019 | this review only | not stated | not extracted yet |
| Mishra 2019 Defining optimum surgical margins in buccoalveolar squamous cell carcinoma. PMID:30777600 | 2019 | this review only | not stated | not extracted yet |
| Nason 2009 What is the adequate margin of surgical resection in oral cancer? DOI:10.1016/j.tripleo.2008.11.013 | 2009 | this review only | not stated | not extracted yet |
| Nason 2009 What is the adequate margin of surgical resection in oral cancer? PMID:19168372 | 2009 | this review only | not stated | not extracted yet |
| Pei 2022 Risk Factors of Microscopically Tumor-Free Surgical Margins for Recurrence and Survival of Oral Squamous Cell Carcinoma Patients. PMID:35875099 | 2022 | this review only | not stated | not extracted yet |
| Priya 2012 Cut margins and disease control in oral cancers DOI:10.4103/0973-1482.95178 | 2012 | this review only | not stated | not extracted yet |
| Priya 2012 Cut margins and disease control in oral cancers. PMID:22531518 | 2012 | this review only | not stated | not extracted yet |
| Quinlan-Davidson 2017 Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy DOI:10.1016/j.oraloncology.2017.07.002 | 2017 | this review only | not stated | not extracted yet |
| Quinlan-Davidson 2017 Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy. PMID:28797467 | 2017 | this review only | not stated | not extracted yet |
| Sambasivan 2021 TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with… DOI:10.1016/j.radonc.2021.04.003 | 2021 | this review only | not stated | not extracted yet |
| Sambasivan 2021 TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with… PMID:33845044 | 2021 | this review only | not stated | not extracted yet |
| Sultania 2023 Margin to Depth of Invasion Ratio: A Significant Predictor of Survival in Patients With Oral Cancer DOI:10.1200/go.23.00144 | 2023 | this review only | not stated | not extracted yet |
| Sultania 2023 Margin to Depth of Invasion Ratio: A Significant Predictor of Survival in Patients With Oral Cancer. PMID:37561980 | 2023 | this review only | not stated | not extracted yet |
| Tsai 2025 Impact of Margin-to-Depth of Invasion Ratio on Oncologic Outcomes in Locally Advanced Oral Cancer Treated With Surgery and… PMID:41554265 | 2026 | this review only | not stated | not extracted yet |
| Tsai 2026 Impact of Margin-to-Depth of Invasion Ratio on Oncologic Outcomes in Locally Advanced Oral Cancer Treated With Surgery and Chemoradiotherapy DOI:10.21053/ceo.2025-00339 | 2026 | this review only | not stated | not extracted yet |
| Varvares 2015 Surgical margins and primary site resection in achieving local control in oral cancer resections DOI:10.1002/lary.25397 | 2015 | this review only | not stated | not extracted yet |
| Varvares 2015 Surgical margins and primary site resection in achieving local control in oral cancer resections. PMID:26011037 | 2015 | this review only | not stated | not extracted yet |
| Wong 2012 Influence of close resection margins on local recurrence and disease-specific survival in oral and oropharyngeal carcinoma DOI:10.1016/j.bjoms.2011.05.008 | 2012 | this review only | not stated | not extracted yet |
| Wong 2012 Influence of close resection margins on local recurrence and disease-specific survival in oral and oropharyngeal carcinoma. PMID:21742422 | 2012 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Impact of surgical margins on recurrence and survival rate in patients with oral squamous cell carcinoma: A systematic review and… (2026) | 5 | 0.06 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Individuals with a pathological diagnosis of oral squamous cell carcinoma | OSCC patients (n=61,863 across 41 studies; 12 countries; aged 16-100 years) |
| Intervention | Poor surgical margin width and low margin to depth of invasion ratio at different cutoff values | Poor SM (n=40 studies); low MDR (n=5 studies) |
| Comparison | Safe surgical margin and safe MDR defined by each study (above the cutoff) | Safe SM or safe MDR as defined by each study |
| Outcomes | Recurrence-free survival, overall survival, disease-free survival | OS (SM n=28, MDR n=4); DFS (SM n=14, MDR n=3); RFS (SM n=21) |
| Study designs | Cohort studies; English language | Cohort studies (n=41) |
| Timing | Not specified | Not specified |