Primary study · included by 2 reviews

The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study.

Menhinick 2004 · Menhinick K A, Gutmann J L, Regan J D, et al. · International endodontic journal · 2004

Included by

Efficacy and safety of single-dose oral postoperative medications in reducing pain after endodontic treatment: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Menhinick 2004 · Table 2; Study characteristics

Outcome this study informs	Pooled effect	Evidence	Certainty
Postoperative pain (VAS) at 6-8 h Single-dose oral Ibuprofen after root canal treatment vs Placebo · 6-8 h after treatment	MD -1.32 [-2.46, -0.17]	3 studies	Moderate
Postoperative pain (VAS) at 6-8 h Any single-dose oral analgesic after root canal treatment (all drugs pooled) vs Placebo · 6-8 h after treatment	MD -2.032 [-2.687, -1.376]	5 studies	GRADE not reported
Postoperative pain (VAS) at 6-8 h Single-dose oral Ibuprofen + Acetaminophen after root canal treatment vs Placebo · 6-8 h after treatment	MD -3.05 [-4.80, -1.30]	2 studies	Moderate

A meta-analysis of pain intensity changes after placebo interventions in facial pain.

Non-Cochrane · other · 2026 · cited as Menhinick 2004 · Results para 1 included-study citation list (ref 81); 116 refs cited for 115 stated studies; Supplemental Tables 1 and 2 not available

The review does not say which of its outcomes this study informs.

2 including reviews in total.