Primary study · included by 1 review

Shibli 2019

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Efficacy of adjunctive antibiotics compared to non-antibiotic therapies following mechanical debridement for peri-implantitis: A systematic review and meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Shibli 2019 · Table 1; Fig 2-5; S3 Fig; S4 Fig

Outcome this study informs	Pooled effect	Evidence	Certainty
Bleeding on probing (BOP, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 3 months	MD -21.21 [-46.04, 3.63]	3 studies · 204 participants	GRADE not reported
Probing pocket depth (PPD, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 3 months	MD -0.93 [-1.54, -0.32]	7 studies · 571 participants	GRADE not reported
Plaque score (PS, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 3 months	MD -5.99 [-11.96, -0.01]	2 studies · 117 participants	GRADE not reported
Bleeding on probing (BOP, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -12.46	11 studies	GRADE not reported
Bleeding on probing (BOP, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 12 months	MD -5.41 [-16.85, 6.03]	6 studies · 194 participants	GRADE not reported
Probing pocket depth (PPD, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -0.69 [-1.04, -0.33]	20 studies · 1076 participants	Moderate
Probing pocket depth (PPD, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 12 months	MD -0.84 [-1.25, -0.42]	8 studies · 262 participants	GRADE not reported
Clinical attachment level (CAL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 6 months	MD -0.05 [-0.06, -0.04]	2 studies · 72 participants	GRADE not reported
Clinical attachment level (CAL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -0.552	7 studies	GRADE not reported
Plaque score (PS, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 6 months	MD -7.4 [-13.76, -1.04]	2 studies · 123 participants	GRADE not reported
Bleeding on probing (BOP, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -12.45 [-24.13, -0.77]	11 studies · 521 participants	GRADE not reported
Bone level (BL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 6 months	MD 0.06 [-0.1, 0.22]	3 studies · 145 participants	GRADE not reported
Clinical attachment level (CAL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -0.55 [-1.07, -0.04]	7 studies · 269 participants	GRADE not reported
Bone level (BL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 12 months	MD 0.05 [-0.16, 0.27]	3 studies · 104 participants	GRADE not reported
Clinical attachment level (CAL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 12 months	MD -0.96 [-1.63, -0.29]	4 studies · 140 participants	GRADE not reported
Bleeding on probing (BOP, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 6 months	MD -9.29 [-20.54, 1.97]	2 studies · 123 participants	GRADE not reported
Probing pocket depth (PPD, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -0.686	20 studies	GRADE not reported
Plaque score (PS, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD -4.07 [-6.8, -1.33]	9 studies · 414 participants	GRADE not reported
Plaque score (PS, % sites) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 12 months	MD -2.39 [-5.9, 1.13]	5 studies · 174 participants	GRADE not reported
Bone level (BL, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other)	MD 0.03 [-0.04, 0.11]	7 studies · 306 participants	GRADE not reported
Probing pocket depth (PPD, mm) Mechanical debridement plus adjunctive antibiotics (local or systemic) vs Mechanical debridement alone or with a non-antibiotic adjunct (probiotics, photodynamic therapy, antiseptic or other) · 6 months	MD -0.11 [-0.59, 0.37]	5 studies · 243 participants	GRADE not reported

1 including review in total.