Primary study · included by 1 review

Santos P 2022

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Comparative efficacy of novel biomaterials versus traditional materials in the treatment of dental and pulpal diseases: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Santos P 2022 · Supplementary Table 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Clinical and radiographic success rate Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 6-24 months	OR 1.12 [0.85, 1.47]	6 studies · 612 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.38 [0.20, 0.71]	2 studies · 220 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.38 [0.16, 0.90]	2 studies · 162 participants	GRADE not reported
Clinical and radiographic success rate Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 6-24 months	OR 1.41 [0.85, 2.34]	6 studies · 612 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.39 [0.27, 0.56]	6 studies · 642 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.40 [0.31, 0.52]	12 studies · 1331 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.40 [0.23, 0.70]	2 studies · 260 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.48 [0.35, 0.66]	12 studies	GRADE not reported

1 including review in total.