Primary study · included by 1 review

Rodrigues GV 2021

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Comparative efficacy of novel biomaterials versus traditional materials in the treatment of dental and pulpal diseases: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Rodrigues GV 2021 · Supplementary Table 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.38 [0.20, 0.71]	2 studies · 220 participants	GRADE not reported
Apical sealing ability / microleakage Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus)	SMD -2.35	6 studies	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.38 [0.16, 0.90]	2 studies · 162 participants	GRADE not reported
Overfilling rate Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus)	OR 2.47 [1.36, 4.49]	5 studies · 503 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.39 [0.27, 0.56]	6 studies · 642 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.40 [0.31, 0.52]	12 studies · 1331 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.40 [0.23, 0.70]	2 studies · 260 participants	GRADE not reported
Postoperative pain incidence (VAS >=4) Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus) · 24-72 h postoperatively	OR 0.48 [0.35, 0.66]	12 studies	GRADE not reported
Apical sealing ability / microleakage Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus)	SMD -1.35 [-1.78, -0.92]	6 studies	GRADE not reported
Overfilling rate Bioceramic (calcium silicate) sealer, single-cone obturation (e.g., iRoot SP, Bio-C Sealer, C-Root SP) vs Epoxy resin-based sealer (AH Plus)	OR 1.85 [1.25, 2.74]	5 studies	GRADE not reported

1 including review in total.