Primary study · included by 1 review

Efficacy of botulinum toxin type a in the targeted treatment of sleep bruxism: a double-blind, randomised, placebo-controlled, cross-over study

Cruse 2022 · Cruse Belinda, Dharmadasa Thanuja, White Elise, et al. · BMJ Neurology Open · 2022

Included by

Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Cruse 2022 · Table 2; References 38-45

Outcome this study informs	Pooled effect	Evidence	Certainty
EMG-based muscle activity, frequency and amplitude Botulinum toxin type A injection into masticatory muscles vs Placebo injection	Hedges g -0.84 [-1.13, -0.54]	5 studies · 101 participants	GRADE not reported
EMG-based muscle activity, frequency and amplitude Botulinum toxin type A injection into masticatory muscles vs Placebo injection · Primary post-treatment time points, typically 2–4 weeks	Hedges g -1.09 [-1.65, -0.54]	5 studies · 101 participants	Low
EMG-based muscle activity, frequency and amplitude Botulinum toxin type A injection into masticatory muscles vs Placebo injection	Hedges g -0.92	4 studies	GRADE not reported
EMG-based muscle activity, frequency and amplitude Botulinum toxin type A injection into masticatory muscles vs Placebo injection	Hedges g -1.34	4 studies	GRADE not reported

1 including review in total.