evidencegaps
Primary study · included by 1 review

Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive‐therapy periodontitis patients

Lappin 2007 · Lappin David F., Sherrabeh Sakhr, Jenkins William M. M., et al. · Journal of Clinical Periodontology · 2007

Included by

A study on the association between smoking, periodontal inflammation and alveolar bone resorption in patients with chronic periodontitis based on biomarkers: a meta-analysis.
Non-Cochrane · aetiology · 2025 · cited as Lappin 2007 · Figure 9; Table 1
Outcome this study informsPooled effectEvidenceCertainty
Receptor activator of nuclear factor kappa-B ligand (RANKL) level in gingival crevicular fluid
Smoking (smoker chronic periodontitis patients) vs Non-smoker chronic periodontitis patients
MD 1.49 [0.85, 2.14]4 studies · 176 participantsGRADE not reported
Osteoprotegerin (OPG) level in gingival crevicular fluid
Smoking (smoker chronic periodontitis patients) vs Non-smoker chronic periodontitis patients
MD -1.52 [-2.98, -0.06]4 studies · 176 participantsGRADE not reported

1 including review in total.