evidencegaps
Primary study · included by 1 review

Flame-sprayed strontium- and magnesium-doped hydroxyapatite on titanium implants for osseointegration enhancement

Wang et al. (2020) · Wang Jheng-Yang, Liu Yu-Cheng, Lin Geng-Sheng, et al. · Surface and Coatings Technology · 2020

Included by

Specific gene expression patterns associated as reliable biomarkers for predicting dental implant successful osseointegration: a literature review and focused meta-analysis.
Non-Cochrane · other · 2025 · cited as Wang 2020 · Table 2; Figure 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
RUNX2 gene expression (relative expression)
Modified titanium implant surface vs Control (unmodified) titanium surface
SMD 5.38 [0.66, 10.1]4 studies · 32 participantsLow
RUNX2 gene expression (relative expression)
Modified titanium implant surface vs Control (unmodified) titanium surface
SMD 2.58 [1.21, 3.95]NRGRADE not reported
Upregulation of pro-osteogenic markers (RUNX2)
Modified implant surface vs Control surface
Not applicable (13 primary studies, including 6 in vitro studies in meta-analysis); LOW13 studiesLow

1 including review in total.