Non-Cochrane · intervention · PM42920807
Systematic Review and Meta-Analysis of Shear Bond Strength after Photodynamic Therapy Versus Conventional Methods for Orthodontic Bracket Bonding : Short title: Shear Bond Strength after Photodynamic Therapy Versus Conventional Methods for Orthodontic Bracket Bonding.
Mirmohammadi Seyed Mohammad Mahdi, Ghanati Ali, Tavazozadeh Elnaz, et al. · Galen medical journal · 2026 · PubMed · doi:10.31661/gmj.v15i.4164
Findings
21 findings
| Population | ||||
|---|---|---|---|---|
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Original fixed-effect estimate | Hedges' g -1.639 GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Hameed et al. (2021) | Hedges' g -4.065 [-5.422, -2.708] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Kamran et al. - Curcumin | Hedges' g -4.011 [-5.420, -2.603] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory | Hedges' g -4.855 GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Alnazeh et al. (2022) | Hedges' g -5.486 [-7.217, -3.754] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Kamran et al. - Rose Bengal | Hedges' g -5.534 [-7.223, -3.846] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Alkhudhairy & Neiva (2023) - Curcumin | Hedges' g -4.262 [-5.603, -2.91] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Baeshen et al. (2021) | Hedges' g -4.297 [-5.770, -2.823] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory | Hedges' g -4.17 [-6.350, -3.361] GRADE not reported 8 studies · 317 participants |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Kamran et al. - Methylene Blue | Hedges' g -4.021 [-5.433, -2.608] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Trim-and-fill adjusted random-effects estimate | Hedges' g -1.55 [-2.36, -0.74] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Kamran et al. - Riboflavin | Hedges' g -4.005 [-5.410, -2.599] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Trim-and-fill adjusted fixed-effect estimate | Hedges' g -1.005 GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Mirhashemi et al. - Methylene Blue | Hedges' g -5.703 [-7.441, -3.966] GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Photodynamic therapy pretreatment | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Leave-one-out: omitted Alkhudhairy & Neiva (2023) - Riboflavin | Hedges' g -4.798 [-6.22, -3.377] GRADE not reported Studies not reported |
| Dental substrates (sound or demineralized enamel, primary teeth, caries-affected dentin) bonded to orthodontic brackets in vitro | Photodynamic therapy pretreatment (any photosensitizer) before bracket bonding | Conventional bonding or non-PDT pretreatment (phosphoric acid etching or untreated control) | Shear bond strength of orthodontic brackets (MPa) In vitro laboratory | SMD -4.28 [-5.57, -2.99] 19.67 vs 15.27 GRADE not reported 8 studies · 317 participants |
| Dental substrates (sound or demineralized enamel, primary teeth, caries-affected dentin) bonded to orthodontic brackets in vitro | Methylene blue-mediated photodynamic therapy pretreatment before bracket bonding | Conventional bonding or non-PDT pretreatment (phosphoric acid etching or untreated control) | Shear bond strength of orthodontic brackets (MPa) In vitro laboratory · Photosensitizer: methylene blue | SMD -5.795 GRADE not reported 6 studies |
| Dental substrates (sound or demineralized enamel, primary teeth, caries-affected dentin) bonded to orthodontic brackets in vitro | Riboflavin-mediated photodynamic therapy pretreatment before bracket bonding | Conventional bonding or non-PDT pretreatment (phosphoric acid etching or untreated control) | Shear bond strength of orthodontic brackets (MPa) In vitro laboratory · Photosensitizer: riboflavin | SMD -3.54 GRADE not reported 3 studies |
| Dental substrates for orthodontic bracket bonding in vitro | Curcumin photodynamic therapy | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Curcumin | Hedges' g -9.36 GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Rose bengal photodynamic therapy | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Rose bengal | Hedges' g -1.42 GRADE not reported Studies not reported |
| Dental substrates for orthodontic bracket bonding in vitro | Indocyanine green photodynamic therapy | Conventional non-PDT bonding pretreatment | Shear bond strength Laboratory · Indocyanine green | Hedges' g -1.26 GRADE not reported Studies not reported |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Alkhudhairy 2023 Effect of Er, Cr: YSGG, Nd: YAG, and diode laser against different photosensitizers on tensile and shear bond strength of bonded composite… PMID:37782152 | 2023 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Alnazeh 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Alnazeh 2026 Photodynamic therapy and argon laser treatment of white spot lesions: Effects on enamel remineralization and orthodontic bracket bond… PMID:41349299 | 2026 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Alqerban 2021 Effectiveness of Riboflavin and Rose Bengal Photosensitizer Modified Adhesive Resin for Orthodontic Bonding. PMID:33435179 | 2021 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Alshami 2021 Shear bond strength of resin modified glass ionomer cement following photodynamic therapy, Er,Cr:YSGG and chlorhexidine in hypoplastic… PMID:34673269 | 2021 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Hameed 2021 Bond assessment of enamel conditioned with Er, Cr: YSGG laser and methylene blue photosensitizer activated by photodynamic therapy to… PMID:34469793 | 2021 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Kamran 2022 Natural and synthetic photosensitizers activated by photodynamic therapy on enamel reconditioning rebonded to metallic brackets: an in… PMID:36591821 | 2022 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
| Mirhashemi 2021 The effect of antimicrobial photodynamic therapy on shear bond strength of orthodontic bracket: An in vitro study. PMID:33677068 | 2021 | this review only | Shear bond strength of orthodontic brackets (MPa) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Any dental substrate (sound or demineralized enamel, primary teeth, dental ceramics) for orthodontic bracket bonding | Sound enamel, demineralized enamel (white spot lesions), enamel reconditioned for bracket rebonding, hypoplastic primary teeth and caries-affected dentin; 317 samples (n=8 studies) |
| Intervention | Any antimicrobial photodynamic therapy protocol (photosensitizer activated by a light source) applied before adhesive application and bracket bonding | PDT with methylene blue (k=6), riboflavin (k=3), curcumin, rose bengal or indocyanine green (13 PDT-control comparisons) |
| Comparison | Standard non-PDT pretreatment for orthodontic bonding, such as phosphoric acid etching | Phosphoric acid etching or untreated controls (13 comparisons) |
| Outcomes | Mean shear bond strength (MPa) with standard deviation | Shear bond strength in MPa (n=8 studies, 13 comparisons); failure mode and adhesive remnant index described narratively |
| Study designs | In vitro studies; English language; no restriction on publication year | In vitro studies (n=8) |
| Timing | Not specified | Not specified |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | Partial Yes | no |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Partial Yes · NRSI: N/A | NRSI: Partial Yes · RCT: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: No · RCT: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | No | no |
| Overall | Critically Low | Critically Low | yes |